Gielen Anke H C, Melenhorst Jarno, Breukink Stephanie O, Weijenberg Matty P, Bours Martijn J L
Department of Surgery, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands.
School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6229 ER Maastricht, The Netherlands.
Cancers (Basel). 2023 Aug 28;15(17):4307. doi: 10.3390/cancers15174307.
Colorectal cancer is one of the most common lifestyle-related types of cancer. The exact pathophysiologic mechanism in the relation between (visceral) adipose tissue, systemic inflammation and colorectal cancer remains unknown. This study aimed to assess the association of lifestyle with markers of systemic inflammation at the time of diagnosis in stage I-III colorectal cancer patients. Patients ( = 298) with stage I-III colorectal cancer from three Dutch hospitals were included at diagnosis. Several lifestyle-related variables (MUST nutritional status score, WCRF/AICR healthy lifestyle score, active smoking, alcohol consumption and BMI) and inflammatory markers (plasma levels of IL-6, IL-8, IL-10, TNFα and 'high sensitive' hsCRP) were measured at the time of diagnosis. Confounder-adjusted multivariable linear regression models were used to analyse how the lifestyle variables were associated with the inflammatory markers. Statistically significant associations were found between a better WCRF/AICR lifestyle score and lower levels of IL-6 and hsCRP. A medium and high risk of malnutrition according to the MUST score was associated with elevated levels of both IL-8 and hsCRP. An overall unhealthier lifestyle indicated by a lower WCRF/AICR lifestyle score and a higher risk of malnutrition according to the MUST score at the time of diagnosis was associated with elevated levels of inflammatory markers. These findings can contribute to formulating lifestyle advice to improve treatment outcomes and prognosis in patients having CRC in the future.
结直肠癌是最常见的与生活方式相关的癌症类型之一。（内脏）脂肪组织、全身炎症与结直肠癌之间的确切病理生理机制尚不清楚。本研究旨在评估I-III期结直肠癌患者诊断时生活方式与全身炎症标志物之间的关联。来自三家荷兰医院的I-III期结直肠癌患者（n = 298）在诊断时被纳入研究。在诊断时测量了几个与生活方式相关的变量（MUST营养状况评分、WCRF/AICR健康生活方式评分、主动吸烟、饮酒和BMI）以及炎症标志物（血浆IL-6、IL-8、IL-10、TNFα水平和“高敏”hsCRP）。使用经混杂因素调整的多变量线性回归模型来分析生活方式变量与炎症标志物之间的关联。发现较好的WCRF/AICR生活方式评分与较低的IL-6和hsCRP水平之间存在统计学显著关联。根据MUST评分，中度和高度营养不良风险与IL-8和hsCRP水平升高相关。诊断时较低的WCRF/AICR生活方式评分和较高的营养不良风险表明总体生活方式不健康，这与炎症标志物水平升高相关。这些发现有助于制定生活方式建议，以改善未来结直肠癌患者的治疗效果和预后。
