Department of Anesthesiology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Department of Anesthesiology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Biomed J. 2021 Aug;44(4):439-446. doi: 10.1016/j.bj.2020.09.001. Epub 2020 Sep 10.
Acute respiratory distress syndrome (ARDS) is difficult to treat and is associated with a high mortality rate. The most severe form of coronavirus disease 2019 (COVID-19) also leads to life-threatening ARDS. Neutrophil counts are positively correlated with disease severity in ARDS. Neutrophil activation not only plays a significant role in immune defense against infections, but also causes tissue damage and leads to inflammatory diseases. Activated neutrophils rapidly migrate to inflamed lung tissue, releasing toxic granular contents and generating neutrophil extracellular traps. In the last few decades, it has become apparent that neutrophils occupy a central role in ARDS pathology. In this review, we summarize the neutrophil inflammatory responses and their relationships to ARDS. According to the current literature, understanding the function of neutrophils may be helpful in the treatment of ARDS.
急性呼吸窘迫综合征（ARDS）难以治疗，且死亡率较高。新型冠状病毒病 2019（COVID-19）最严重的形式也会导致危及生命的 ARDS。中性粒细胞计数与 ARDS 的疾病严重程度呈正相关。中性粒细胞的激活不仅在针对感染的免疫防御中起重要作用，而且还会导致组织损伤并引发炎症性疾病。活化的中性粒细胞迅速迁移到发炎的肺组织，释放出有毒的颗粒内容物并产生中性粒细胞胞外陷阱。在过去几十年中，中性粒细胞在 ARDS 病理中占据核心地位这一点已变得很明显。在这篇综述中，我们总结了中性粒细胞的炎症反应及其与 ARDS 的关系。根据目前的文献，了解中性粒细胞的功能可能有助于治疗 ARDS。
