Johannsen Benita, Mark Daniel, Boillat-Blanco Noémie, Fresco Alain, Baumgartner Desirée, Zengerle Roland, Mitsakakis Konstantinos
Hahn-Schickard, Freiburg, Germany.
Spindiag GmbH, Freiburg, Germany.
Stud Health Technol Inform. 2020 Sep 4;273:234-239. doi: 10.3233/SHTI200646.
Respiratory Tract Infections (RTIs) are among the top reasons for visiting a General Practitioner (GP) and the main cause of unnecessary antibiotic prescriptions. Reducing inappropriate use is essential to decrease antibiotic resistance and adverse events. The goal of the Eurostars project "Respiotic" is to develop a new point-of-care (POC) platform based on the centrifugal microfluidic LabDisk that will detect the main responsible viruses and bacteria for community-acquired RTIs, including associated resistances and host biomarkers. The diagnostic platform will use a Polymerase Chain Reaction (PCR) and an immunoassay cartridge on the same instrument and provide the combined analysis within less than 1 h. An electronic clinical algorithm will co-assess the test results and act as a decision support tool for the GPs' patient management and prescriptions.
呼吸道感染（RTIs）是患者拜访全科医生（GP）的主要原因之一，也是不必要抗生素处方的主要成因。减少不当使用对抗生素耐药性和不良事件的降低至关重要。欧洲之星项目“Respiotic”的目标是基于离心微流控LabDisk开发一个新的即时检测（POC）平台，该平台将检测社区获得性呼吸道感染的主要致病病毒和细菌，包括相关耐药性和宿主生物标志物。该诊断平台将在同一仪器上使用聚合酶链反应（PCR）和免疫分析试剂盒，并在不到1小时内提供联合分析。一个电子临床算法将共同评估检测结果，并作为全科医生患者管理和处方的决策支持工具。
