Department of Geriatrics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui, 230001, People's Republic of China.
Department of Geriatrics, Qilu Hospital of Shandong University, Shandong, 250012, People's Republic of China.
Endocr J. 2021 Feb 28;68(2):137-144. doi: 10.1507/endocrj.EJ20-0186. Epub 2020 Oct 20.
Serum osteocalcin (OCN) is closely related to metabolic risk factors, and the relationship between OCN and atherosclerosis has been investigated. However, it is still controversial. Herein, we explored the potential correlation between serum total OCN and lower extremity atherosclerotic disease (LEAD) in 326 hospitalized Chinese patients with type 2 diabetes mellitus (T2DM). Femoral intima-media thickness (F-IMT) and lower limb atherosclerotic plaque were assessed through color Doppler ultrasound. Subjects with LEAD had significantly lower serum OCN levels compared with those without LEAD (14.54 [14.10-14.89] ng/mL versus 16.79 [15.86-18.04] ng/mL, p < 0.001). Spearman's correlation analysis revealed that serum OCN levels were positively associated with high density lipoprotein cholesterol (HDL-C) and negatively associated with fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (2hPG), hemoglobin A1c (HbA1c), waist-to-hip ratio (WHR) and F-IMT. Multiple logistic analysis revealed that OCN (OR 0.938, 95% confidence interval (CI 0.933-0.950, p = 0.003) and glomerular filtration rate (GFR) (OR 0.990, 95% CI 0.985-0.996, p = 0.003) were independently and inversely associated with LEAD, while age (OR 1.140, 95% CI 1.127-1.148, p < 0.001), diabetes duration (OR 1.068, 95% CI 1.039-1.080, p < 0.005) and uric acid (UA) (OR 1.005, 95% CI 1.002-1.007, p = 0.032) were independently and positively associated with LEAD. Additionally, multiple linear regression analysis revealed that serum OCN levels were negatively associated with F-IMT (standardized β = -0.180, p = 0.002). In Chinese patients with T2DM, serum OCN levels were independently and inversely correlated with LEAD.
血清骨钙素（OCN）与代谢危险因素密切相关，OCN 与动脉粥样硬化的关系已被研究。然而，这仍然存在争议。在此，我们研究了 326 例中国 2 型糖尿病（T2DM）住院患者的血清总 OCN 与下肢动脉粥样硬化疾病（LEAD）之间的潜在相关性。通过彩色多普勒超声评估股内中膜厚度（F-IMT）和下肢动脉粥样硬化斑块。与无 LEAD 患者相比，LEAD 患者的血清 OCN 水平显著降低（14.54[14.10-14.89]ng/mL 与 16.79[15.86-18.04]ng/mL，p<0.001）。Spearman 相关分析显示，血清 OCN 水平与高密度脂蛋白胆固醇（HDL-C）呈正相关，与空腹血糖（FPG）、餐后 2 小时血糖（2hPG）、糖化血红蛋白（HbA1c）、腰臀比（WHR）和 F-IMT 呈负相关。多因素逻辑回归分析显示，OCN（OR0.938，95%置信区间（CI）0.933-0.950，p=0.003）和肾小球滤过率（GFR）（OR0.990，95%CI0.985-0.996，p=0.003）与 LEAD 呈独立负相关，而年龄（OR1.140，95%CI1.127-1.148，p<0.001）、糖尿病病程（OR1.068，95%CI1.039-1.080，p<0.005）和尿酸（UA）（OR1.005，95%CI1.002-1.007，p=0.032）与 LEAD 呈独立正相关。此外，多元线性回归分析显示，血清 OCN 水平与 F-IMT 呈负相关（标准化β=-0.180，p=0.002）。在中国 T2DM 患者中，血清 OCN 水平与 LEAD 呈独立负相关。
