Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.
Diabetes Res Clin Pract. 2011 Jun;92(3):393-9. doi: 10.1016/j.diabres.2011.03.015. Epub 2011 Apr 3.
Although accumulating evidence suggests that osteocalcin, which is secreted in circulation specifically from osteoblasts, is involved in glucose and lipid metabolism, it is unclear whether serum osteocalcin is associated with atherosclerosis parameter in humans.
We monitored chronological changes in bone turnover markers and a parameter of atherosclerosis, plaque score (PS), during glycemic control in Japanese patients with type 2 diabetes, and analyzed relationships among these parameters.
Multiple regression analysis showed that changes in osteocalcin were negatively correlated with changes in HbA(1c) (β = -0.38, p = 0.01). Baseline osteocalcin was negatively correlated with changes in triglycerides (β = -0.29, p = 0.03) and positively with changes in HDL-cholesterol (β = 0.31, p = 0.03), and that changes in osteocalcin were negatively correlated with baseline triglyceride (β = -0.35, p = 0.02). Changes in osteocalcin were positively correlated with baseline PS (β = 0.35, p = 0.01) and negatively with changes in PS (β = -0.30, p < 0.05) independent of other conventional risk factors of atherosclerosis.
These findings indicated the association between serum osteocalcin and glucose and lipid metabolism as well as an atherosclerosis parameter independently of other atherosclerosis-related risk factors in patients with type 2 diabetes, suggesting that osteocalcin is important for not only bone metabolism but also glucose and lipid metabolism as well as atherosclerosis.
尽管越来越多的证据表明，骨钙素是一种专门由成骨细胞分泌到循环中的物质，它参与葡萄糖和脂质代谢，但血清骨钙素与人类动脉粥样硬化参数之间的关系尚不清楚。
我们监测了 2 型糖尿病日本患者在血糖控制过程中骨转换标志物和动脉粥样硬化参数斑块评分（PS）的时间变化，并分析了这些参数之间的关系。
多元回归分析显示，骨钙素的变化与 HbA1c 的变化呈负相关（β=-0.38，p=0.01）。基线骨钙素与甘油三酯的变化呈负相关（β=-0.29，p=0.03），与高密度脂蛋白胆固醇的变化呈正相关（β=0.31，p=0.03），而骨钙素的变化与基线甘油三酯呈负相关（β=-0.35，p=0.02）。骨钙素的变化与基线 PS 呈正相关（β=0.35，p=0.01），与 PS 的变化呈负相关（β=-0.30，p<0.05），独立于其他动脉粥样硬化的常规危险因素。
这些发现表明，血清骨钙素与葡萄糖和脂质代谢以及动脉粥样硬化参数之间存在关联，而与其他动脉粥样硬化相关危险因素无关，这表明骨钙素不仅对骨代谢重要，而且对葡萄糖和脂质代谢以及动脉粥样硬化也很重要。
