Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Doha, Qatar.
College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.
Sci Rep. 2020 Oct 21;10(1):17918. doi: 10.1038/s41598-020-74864-6.
The relationship between salivary α-amylase activity (psAAa) or AMY1 copy number and the risk of obesity remains controversial. We aimed to assess this relationship in a cohort from Qatar, where obesity affects 43% of adults. The relationship was investigated cross-sectionally in 923 Qatari adults from the Qatar biobank cohort. AMY1 CN was estimated form whole genome sequencing data. The associations with obesity prevalence were assessed by linear and logistic regressions. We found no difference in AMY1 CN between obese and normal-weight individuals. However, the psAAa was significantly lower in obese individuals. Significant inverse correlations were found between adiposity markers and psAAa in both sexes, but were marginally stronger in men. A significant effect of high psAAa, but not AMY1 CN, on reduced obesity rates was identified in men (OR per psAAa unit 0.957 [95% CI 0.937-0.977], p < 0.001, with psAAa ranging between 5 to 66 U/L). A significantly higher prevalence of obesity was observed in the lowest quartile of psAAa in men (75% (Q1) vs. 36% (Q4), p < 0.001) and women (74% (Q1) vs 56% (Q4), p = 0.009). Our findings suggest that high psAAa, but not AMY1 CN, has a potential positive benefit against obesity in the Qatari population.
唾液α-淀粉酶活性（psAAa）或 AMY1 拷贝数与肥胖风险之间的关系仍存在争议。我们旨在评估卡塔尔队列中的这种关系，在那里肥胖影响 43%的成年人。在来自卡塔尔生物库队列的 923 名卡塔尔成年人中，我们进行了横断面研究。使用全基因组测序数据估计 AMY1 CN。通过线性和逻辑回归评估与肥胖患病率的关联。我们没有发现肥胖个体和正常体重个体之间的 AMY1 CN 存在差异。然而，肥胖个体的 psAAa 明显较低。在两性中，均发现肥胖标志物与 psAAa 之间存在显著的负相关，但在男性中相关性略强。在男性中，发现高 psAAa（而非 AMY1 CN）对降低肥胖率有显著影响（每单位 psAAa 的 OR 为 0.957 [95%CI 0.937-0.977]，p<0.001，psAAa 范围为 5 至 66 U/L）。在男性中，观察到 psAAa 最低四分位数的肥胖患病率显著更高（75%（Q1）与 36%（Q4），p<0.001）和女性（74%（Q1）与 56%（Q4），p=0.009）。我们的研究结果表明，高 psAAa（而非 AMY1 CN）可能对卡塔尔人群的肥胖有积极的益处。
