Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Nat Rev Immunol. 2020 Dec;20(12):715-716. doi: 10.1038/s41577-020-00472-0.
The ethics and practicalities of controlled human infection with SARS-CoV-2 have been widely discussed. Potential risks are clear. The case in favour hinges upon whether these risks can be mitigated to an acceptable, very low, level and whether the studies will provide substantial benefits that could not readily be obtained by other means. Here, we discuss the immunological considerations relating to each side of this balance.
用 SARS-CoV-2 对人类进行可控感染的伦理和实际问题已被广泛讨论。潜在风险显而易见。支持该做法的依据在于这些风险能否被降低到可接受的、非常低的水平，以及这些研究是否能带来无法通过其他方法轻易获得的实质性益处。在此，我们讨论与这一平衡的每一方面相关的免疫学考虑因素。
