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用于牙龈退缩的α-肾上腺素能激动剂评估:一项随机交叉临床试验。

Evaluation of alpha-adrenomimetic agents for gingival retraction: A randomized crossover clinical trial.

作者信息

Mehra Neha, Rathi Ajita, Sharma Roshni, Kaushik Mamta, Sood Tanushree

机构信息

Department of Conservative Dentistry and Endodontics, Army College of Dental Sciences, Secunderabad, Telangana, India.

Private Practitioner, Vidyaranyapuram, Mysuru, Karnataka, India.

出版信息

J Conserv Dent. 2019 Nov-Dec;22(6):533-537. doi: 10.4103/JCD.JCD_76_19. Epub 2020 Aug 20.

DOI:10.4103/JCD.JCD_76_19
PMID:33088060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7542084/
Abstract

CONTEXT

The displacement of the gingiva around the tooth allows proper access during preparation, precise impression taking, and cementation procedures that has a direct bearing on the health of the periodontium. Several methods and agents are used for this purpose.

AIMS

The primary aim of the study was to clinically evaluate the efficacy of naphazoline as a gingival retraction agent. The secondary aim was to compare it with tetrahydrozoline and aluminum chloride.

SETTINGS AND DESIGN

Fifteen patients participated in a randomized crossover clinical trial at the Army College of Dental Sciences, Secunderabad, Telangana, India.

SUBJECTS AND METHODS

Preliminary maxillary impressions were made with irreversible hydrocolloid for all patients to fabricate custom trays. After that, baseline impressions and cast for control group measurements were prepared. Gingival displacement was carried out in the right maxillary central incisor for all, with retraction cord soaked in three agents, either, aluminum chloride, tetrahydrozoline, or naphazoline. These agents were used in all patients with a washout period of 14 days. Elastomeric monophase impressions and die stone casts were recorded for each group. The central incisors were sectioned, and gingival retraction was measured using a measuring stereomicroscope.

STATISTICAL ANALYSIS USED

The gingival displacement was statistically analyzed using one-way ANOVA and Bonferroni.

RESULTS

Naphazoline had the highest retraction (138.160 μm) followed by tetrahydrozoline (136.039 μm) and aluminum chloride (130.759 μm).

CONCLUSIONS

Naphazoline, tetrahydrozoline, and aluminum chloride show a clinically and statistically significant amount of displacement when compared to control. Among the three agents, naphazoline showed maximum displacement and maybe a good alternative with fewer side effects.

摘要

背景

牙齿周围牙龈的移位有助于在牙体预备、精确取印模和粘接操作过程中获得适当的操作空间,这对牙周组织的健康有直接影响。为此使用了多种方法和制剂。

目的

本研究的主要目的是临床评估萘甲唑啉作为牙龈收缩剂的疗效。次要目的是将其与四氢唑啉和氯化铝进行比较。

设置与设计

15名患者参与了在印度特伦甘纳邦塞康德拉巴德陆军牙科学院进行的一项随机交叉临床试验。

对象与方法

所有患者均使用不可逆水胶体制作初步的上颌印模,以制作定制托盘。之后,为对照组制作基线印模和模型以进行测量。对所有人的右上颌中切牙进行牙龈移位操作,将收缩线浸泡在三种制剂中,即氯化铝、四氢唑啉或萘甲唑啉。所有患者均使用这些制剂,洗脱期为14天。为每组记录弹性单相印模和石膏模型。将中切牙切片,使用测量体视显微镜测量牙龈退缩情况。

所用统计分析方法

使用单因素方差分析和Bonferroni法对牙龈移位进行统计学分析。

结果

萘甲唑啉的退缩量最高(138.160μm),其次是四氢唑啉(136.039μm)和氯化铝(130.759μm)。

结论

与对照组相比,萘甲唑啉、四氢唑啉和氯化铝在临床上和统计学上均显示出显著的移位量。在这三种制剂中,萘甲唑啉显示出最大的移位量,可能是一种副作用较少的良好替代品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d54/7542084/00cd62fea818/JCD-22-533-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d54/7542084/a193c9bd3260/JCD-22-533-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d54/7542084/00cd62fea818/JCD-22-533-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d54/7542084/a193c9bd3260/JCD-22-533-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d54/7542084/00cd62fea818/JCD-22-533-g002.jpg

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本文引用的文献

1
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Contemp Clin Dent. 2015 Apr-Jun;6(2):189-95. doi: 10.4103/0976-237X.156043.
2
Cytotoxic potential of vasoconstrictor experimental gingival retraction agents: in vitro study on primary human gingival fibroblasts.血管收缩剂类实验性牙龈退缩剂的细胞毒性潜力:对原代人牙龈成纤维细胞的体外研究
Folia Biol (Praha). 2012;58(1):37-43.
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Dynamic oxidoreductive potential of astringent retraction agents.
收敛性收缩剂的动态氧化还原电位
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