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峡蛋白2在子痫前期中表达降低，而在绒毛膜癌中高表达。

Isthmin 2 is decreased in preeclampsia and highly expressed in choriocarcinoma.

作者信息

Martinez Cynthia, González-Ramírez Javier, Marín María E, Martínez-Coronilla Gustavo, Meza-Reyna Vanessa I, Mora Rafael, Díaz-Molina Raul

机构信息

Department of Obstetrics and Gynecology, Maternity and Children Hospital, Mexicali, B.C., 21376, Mexico.

Faculty of Nursing, University Autonomous of Baja California, Mexicali, B.C., 21100, Mexico.

出版信息

Heliyon. 2020 Oct 13;6(10):e05096. doi: 10.1016/j.heliyon.2020.e05096. eCollection 2020 Oct.

DOI:10.1016/j.heliyon.2020.e05096
PMID:33088937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7567920/
Abstract

INTRODUCTION

Isthmin 2 (ISM2) is a protein which expression in humans is almost specific to the placenta. There is no previous report in the literature that investigated this protein in preeclampsia or choriocarcinoma.

METHODS

We conducted a prospective, cross-sectional study that included women with preeclampsia, gestational hypertension and normotensive pregnancy. We measured serum concentrations of ISM2 protein and performed immunohistochemistry in placenta tissues. We also performed immunohistochemistry of ISM2 in samples from choriocarcinoma and compare with lung, prostate, colon, gastric and breast cancers.

RESULTS

A total of 81 patients were included, 30 with preeclampsia, 21 with gestational hypertension and 30 controls. The ISM2 protein was found to be decreased in patients with preeclampsia compared to the control group (P = 0.036). These results were confirmed by immunohistochemistry. We also found that ISM2 protein was overexpressed in choriocarcinoma.

DISCUSSION

Taken together, our results suggest an angiogenic function for ISM2. Its serum level decreased in our patients with preeclampsia could be reflecting that it is involved in the pathogenesis of the disease; on the other hand its high expression in choriocarcinoma, indicates that ISM2 may play an active role in the angiogenesis of this and other cancers.

摘要

引言

肌动蛋白结合蛋白2（ISM2）是一种在人类中几乎仅在胎盘中表达的蛋白质。此前文献中没有关于子痫前期或绒毛膜癌中该蛋白的研究报道。

方法

我们进行了一项前瞻性横断面研究，纳入了患有子痫前期、妊娠期高血压和血压正常的孕妇。我们测量了血清中ISM2蛋白的浓度，并对胎盘组织进行了免疫组织化学检测。我们还对绒毛膜癌样本进行了ISM2免疫组织化学检测，并与肺癌、前列腺癌、结肠癌、胃癌和乳腺癌进行了比较。

结果

共纳入81例患者，其中子痫前期患者30例，妊娠期高血压患者21例，对照组30例。与对照组相比，子痫前期患者的ISM2蛋白水平降低（P = 0.036）。免疫组织化学证实了这些结果。我们还发现ISM2蛋白在绒毛膜癌中过表达。

讨论

综上所述，我们的结果提示ISM2具有血管生成功能。子痫前期患者血清中其水平降低可能反映其参与了该疾病的发病机制；另一方面，其在绒毛膜癌中的高表达表明ISM2可能在该癌症及其他癌症的血管生成中发挥积极作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f15/7567920/eebe64ecd68f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f15/7567920/f96f9250a374/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f15/7567920/2e0cce82a345/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f15/7567920/eebe64ecd68f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f15/7567920/f96f9250a374/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f15/7567920/2e0cce82a345/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f15/7567920/eebe64ecd68f/gr3.jpg

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