通过液化二甲醚进行甘氨酸的无乙醇反溶剂结晶。

Ethanol-free antisolvent crystallization of glycine by liquefied dimethyl ether.

作者信息

Kanda Hideki, Katsube Tsubasa, Hoshino Rintaro, Kishino Mitsuhiro, Goto Motonobu

机构信息

Department of Materials Process Engineering, Nagoya University, Furocho, Chikusa, Nagoya, 464-8603, Japan.

PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan.

出版信息

Heliyon. 2020 Oct 14;6(10):e05258. doi: 10.1016/j.heliyon.2020.e05258. eCollection 2020 Oct.

DOI:10.1016/j.heliyon.2020.e05258

PMID:33088982

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7567939/

Abstract

Liquefied dimethyl ether (DME) was employed as an antisolvent to crystallize glycine from its aqueous solution. The proposed method can be performed at 20-25 °C and has the potential to reduce the energy consumption of drying or crystallizing using ethanol. α-Glycine crystals were successfully obtained from glycine aqueous solutions by mixing in liquefied DME, which was easily removed from the crystals by decompression. Contact with a liquefied DME/water mixture and small γ-glycine crystals resulted in the α-glycine converting to γ-glycine. This was only observed for saturated glycine solutions. We speculated that this conversion occurs via a solution-mediated transition. Pure liquefied DME is not capable of promoting solvent-mediated transitions, so saturated glycine solutions treated with the pure antisolvent can give α-glycine as the sole product.

摘要

液化二甲醚（DME）被用作抗溶剂，从甘氨酸水溶液中结晶出甘氨酸。所提出的方法可在20 - 25°C下进行，并且有潜力降低使用乙醇进行干燥或结晶的能耗。通过在液化DME中混合，成功地从甘氨酸水溶液中获得了α - 甘氨酸晶体，通过减压可轻松地从晶体中除去DME。与液化DME/水混合物和小的γ - 甘氨酸晶体接触会导致α - 甘氨酸转化为γ - 甘氨酸。这仅在饱和甘氨酸溶液中观察到。我们推测这种转化是通过溶液介导的转变发生的。纯液化DME不能促进溶剂介导的转变，因此用纯抗溶剂处理的饱和甘氨酸溶液可以得到α - 甘氨酸作为唯一产物。