Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, 272029, Shandong, China.
Hefei National Laboratory for Physical Science At Microscale and School of Life Science, University of Science and Technology of China, Hefei, 230026, Anhui, China.
Biomol NMR Assign. 2021 Apr;15(1):41-44. doi: 10.1007/s12104-020-09980-5. Epub 2020 Oct 21.
The autoantigen La protein is a conserved component of eukaryotic ribonucleoprotein complexes that binds the 3' poly(U) sequences of nascent RNA polymerase III transcripts to assist folding and maturation. This specific recognition is mediated by the N-terminal domain (NTD) of La, which comprises a La motif and an RNA recognition motif (RRM). Here, we report near complete H, C and N backbone and sidechain assignments for the RRM domain of La protein from Trypanosoma brucei.
自身抗原 La 蛋白是真核核糖核蛋白复合物的保守成分，它与新生 RNA 聚合酶 III 转录本的 3' 聚（U）序列结合，以协助折叠和成熟。这种特异性识别由 La 的 N 端结构域（NTD）介导，它包含一个 La 基序和一个 RNA 识别基序（RRM）。在这里，我们报道了来自布氏锥虫的 La 蛋白的 RRM 结构域的 H、C 和 N 骨架及侧链的几乎完整的归属。
