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TbBDF5-溴代结构域的 H、C 和 N 共振归属来自于布氏锥虫。

H, C and N resonance assignments of TbBDF5-bromo1 domain from Trypanosoma brucei.

机构信息

MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, Anhui, China.

出版信息

Biomol NMR Assign. 2022 Oct;16(2):253-255. doi: 10.1007/s12104-022-10088-1. Epub 2022 Jun 2.

DOI:10.1007/s12104-022-10088-1
PMID:35652998
Abstract

H, C and N resonance assignments are presented for the first bromo domain of TbBDF5 (TbBDF5-bromo1) from Trypanosoma brucei. TbBDF5 is localized in the nucleus and plays a potential role in transcription regulation. Bromo domains can recognize acetylated histone through a conserved binding pocket. Here we report the NMR resonance assignments of TbBDF5-bromo1 domain for further studies of the relationship between its structure and function.

摘要

H、C 和 N 共振分配呈现为来自布氏锥虫的 TbBDF5（TbBDF5-溴域 1）的第一个溴结构域。TbBDF5 定位于细胞核中，在转录调控中发挥潜在作用。溴结构域可以通过保守的结合口袋识别乙酰化组蛋白。在此，我们报告了 TbBDF5-溴域的 NMR 共振分配，以便进一步研究其结构与功能之间的关系。

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