MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, Anhui, China.
Biomol NMR Assign. 2022 Oct;16(2):253-255. doi: 10.1007/s12104-022-10088-1. Epub 2022 Jun 2.
H, C and N resonance assignments are presented for the first bromo domain of TbBDF5 (TbBDF5-bromo1) from Trypanosoma brucei. TbBDF5 is localized in the nucleus and plays a potential role in transcription regulation. Bromo domains can recognize acetylated histone through a conserved binding pocket. Here we report the NMR resonance assignments of TbBDF5-bromo1 domain for further studies of the relationship between its structure and function.
H、C 和 N 共振分配呈现为来自布氏锥虫的 TbBDF5（TbBDF5-溴域 1）的第一个溴结构域。TbBDF5 定位于细胞核中，在转录调控中发挥潜在作用。溴结构域可以通过保守的结合口袋识别乙酰化组蛋白。在此，我们报告了 TbBDF5-溴域的 NMR 共振分配，以便进一步研究其结构与功能之间的关系。
