Gönen Murat, Özdoğan Sevim, Balgetir Ferhat, Demir Caner Feyzi, Aytaç Emrah, Müngen Bülent
Department of Neurology, Faculty of Medicine, Firat University, Elazig, Turkey.
Department of Neurology, Kayseri City Hospital, Kayseri, Turkey.
Acta Neurol Scand. 2021 Mar;143(3):298-302. doi: 10.1111/ane.13365. Epub 2020 Nov 8.
In recent years, radiological and biochemical data have emerged regarding the development of cellular damage in the brain of patients with migraine, calling into question what has traditionally been accepted as a benign disorder. In order to investigate whether cellular damage develops in the brain of episodic migraine patient, serum levels of neuron-specific enolase (NSE) and S100B have been evaluated in recent studies. However, contradictory results were obtained in these studies. Moreover, there is no study on NSE and S100B in cases of chronic migraine.
Patients with episodic migraine with or without aura and chronic migraine were included. In addition, 27 healthy volunteers were included as a control group. Control group was selected from healthy volunteers of the same age and sex. We investigated serum NSE and S100B levels during the interictal period in 26 patients with episodic migraine and 27 patients with chronic migraine.
The serum NSE and S100B levels were significantly higher in both patients with episodic and chronic migraine than controls. Although there were no significant differences in the serum NSE and S100B levels between the two patients' groups, these markers were found to be higher in cases of chronic migraine.
These results suggest that there is both neuronal and glial involvement in the two migraine groups. Elevations in these markers in cases of episodic migraine suggest that cellular damage not only results from headache episodes, but that there may be also an ongoing pathological process during the interictal period.
近年来，有关偏头痛患者脑部细胞损伤发展的放射学和生化数据不断涌现，这使得传统上被认为是良性疾病的观点受到质疑。为了研究发作性偏头痛患者的脑部是否会发生细胞损伤，近期研究对血清神经元特异性烯醇化酶（NSE）和S100B水平进行了评估。然而，这些研究得出了相互矛盾的结果。此外，尚无关于慢性偏头痛患者NSE和S100B的研究。
纳入有或无先兆的发作性偏头痛患者以及慢性偏头痛患者。此外，纳入27名健康志愿者作为对照组。对照组从年龄和性别相同的健康志愿者中选取。我们调查了26例发作性偏头痛患者和27例慢性偏头痛患者发作间期的血清NSE和S100B水平。
发作性偏头痛患者和慢性偏头痛患者的血清NSE和S100B水平均显著高于对照组。虽然两组患者的血清NSE和S100B水平无显著差异，但发现这些标志物在慢性偏头痛患者中更高。
这些结果表明，在这两种偏头痛类型中均存在神经元和神经胶质细胞受累的情况。发作性偏头痛患者这些标志物的升高表明，细胞损伤不仅源于头痛发作，而且在发作间期可能也存在持续的病理过程。
