Department Cardiovascular Medicine, The 196534Second Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, China.
Department Health Care Centre, The 117970First Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, China.
Am J Alzheimers Dis Other Demen. 2020 Jan-Dec;35:1533317520962660. doi: 10.1177/1533317520962660.
There are currently no established, clinically relevant, non-invasive markers of cognitive impairment, except for age and APOE genotype.
A cross-sectional study of 1,296 participants from Nanchang, China, has been conducted. We collected data from Mini-Mental State Examination (MMSE) scores, internal lipid profiles and body lipid profiles, age and other factors that may have an effect on cognitive impairment.
Internal lipid profiles (OR = 1.03 [95%CI, 1.00-1.06], = ), body lipid profiles (OR = 1.05 [95%CI, 1.01-1.09], = 0.014), and age (OR = 1.03 [95%CI, 1.01-1.05], 0.001) were all positively correlated with cognitive impairment.
Cognitive impairment was more frequent in female patients with high internal lipid profiles or body lipid profiles, and these characteristics were related to age and education.
目前，除了年龄和 APOE 基因型外，尚无明确的、与临床相关的认知障碍的非侵入性标志物。
在中国南昌进行了一项横断面研究，共纳入 1296 名参与者。我们收集了来自简易精神状态检查（MMSE）评分、内部脂质谱和身体脂质谱、年龄和其他可能影响认知障碍的因素的数据。
内部脂质谱（OR=1.03[95%CI，1.00-1.06]，=）、身体脂质谱（OR=1.05[95%CI，1.01-1.09]，=0.014）和年龄（OR=1.03[95%CI，1.01-1.05]，=0.001）与认知障碍均呈正相关。
高内部脂质谱或身体脂质谱的女性患者更易发生认知障碍，这些特征与年龄和教育程度有关。
