从 var. (C.B.Clarke) Kitam.中分离得到一个新的高含氧裂环二萜烯。

A new highly oxygenated germacranolide from var. (C.B.Clarke) Kitam.

机构信息

School of Pharmacy, Lanzhou University, Lanzhou, People's Republic of China.

State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, People's Republic of China.

出版信息

Nat Prod Res. 2022 May;36(9):2306-2313. doi: 10.1080/14786419.2020.1833199. Epub 2020 Oct 22.

DOI:10.1080/14786419.2020.1833199

PMID:33089720

Abstract

A new highly oxygenated germacranolide, carcerlane A (), together with four known highly oxygenated germacranolides (-), was isolated from an ethanol extract of the whole plant of var. (C.B.Clarke) Kitam. The structures were determined by HRESIMS and extensive analysis of their spectroscopic data including IR, 1 D and 2 D NMR spectra. To our best knowledge, it was the first time to report the phytochemical investigation on this plant. The anti-Alzheimer's disease (AD) activities of - were evaluated using AD pathological model. All the tested compounds showed that they have the anti-AD bioactivities of delaying worms paralysis.

摘要

从全株 var. (C.B.Clarke) Kitam 的乙醇提取物中分离得到一种新的高度氧化的倍半萜内酯化合物，carcerlane A ()，并与四个已知的高度氧化的倍半萜内酯 (-)一起分离得到。通过高分辨质谱（HRESIMS）和对其包括 IR、1D 和 2D NMR 光谱在内的光谱数据的广泛分析确定了结构。据我们所知，这是首次对该植物进行植物化学研究。使用 AD 病理模型评估了 - 对阿尔茨海默病（AD）的活性。所有测试的化合物均表明它们具有延缓蠕虫麻痹的抗 AD 生物活性。