School of Pharmacy, Lanzhou University, Lanzhou, People's Republic of China.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, People's Republic of China.
Nat Prod Res. 2022 May;36(9):2306-2313. doi: 10.1080/14786419.2020.1833199. Epub 2020 Oct 22.
A new highly oxygenated germacranolide, carcerlane A (), together with four known highly oxygenated germacranolides (-), was isolated from an ethanol extract of the whole plant of var. (C.B.Clarke) Kitam. The structures were determined by HRESIMS and extensive analysis of their spectroscopic data including IR, 1 D and 2 D NMR spectra. To our best knowledge, it was the first time to report the phytochemical investigation on this plant. The anti-Alzheimer's disease (AD) activities of - were evaluated using AD pathological model. All the tested compounds showed that they have the anti-AD bioactivities of delaying worms paralysis.
从全株 var. (C.B.Clarke) Kitam 的乙醇提取物中分离得到一种新的高度氧化的倍半萜内酯化合物，carcerlane A ()，并与四个已知的高度氧化的倍半萜内酯 (-)一起分离得到。通过高分辨质谱（HRESIMS）和对其包括 IR、1D 和 2D NMR 光谱在内的光谱数据的广泛分析确定了结构。据我们所知，这是首次对该植物进行植物化学研究。使用 AD 病理模型评估了 - 对阿尔茨海默病（AD）的活性。所有测试的化合物均表明它们具有延缓蠕虫麻痹的抗 AD 生物活性。
