母体职业性烟草暴露与新生儿脐血清瘦素浓度。

Maternal Occupational Tobacco Exposure and Newborn Umbilical Cord Serum Leptin Concentration.

机构信息

Department of Community Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, India.

Department of Biochemistry, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, India.

出版信息

Indian Pediatr. 2020 Oct 15;57(10):918-921.

PMID:33089807

Abstract

OBJECTIVE

To assess the effect of maternal occupational tobacco handling (bidi rolling) on cord serum leptin levels.

METHODS

We enrolled 64 neonates born to women who were bidi-rollers, and 64 small for gestational age (SGA) neonates and 57 term appropriate for gestational age (AGA) neonates born to mothers with no tobacco exposure. Cord blood leptin levels between the groups were compared. Adjusted mean difference in leptin was calculated using regression model.

RESULTS

Cord leptin showed moderate correlation with birthweight (r=0.16; P=0.027) across the groups. Mean (SD) cord serum leptin levels (ng/mL) of study group was 19.79 (13.32), in comparison to 21.4 (13.4) of SGA (P=0.497), and 27.70 (13.96) of term AGA (P=0.002). Maternal occupational tobacco exposure contributed to significant decrease in cord leptin (adjusted mean difference (95%CI): -4.5 ng/mL (-8.82, -0.19); P=0.041).

CONCLUSIONS

Maternal occupational tobacco exposure causes signifi-cant reduction in fetal leptin levels.

摘要

目的

评估母体职业性烟草接触（比迪烟卷制）对脐血清瘦素水平的影响。

方法

我们纳入了 64 名母亲为比迪烟卷制工的新生儿，64 名因母亲无烟草暴露而出生的小于胎龄儿（SGA）新生儿和 57 名适于胎龄儿（AGA）新生儿。比较各组之间的脐血瘦素水平。使用回归模型计算瘦素的调整平均差异。

结果

各组中，脐瘦素与出生体重呈中度相关（r=0.16；P=0.027）。研究组的平均（SD）脐血清瘦素水平（ng/mL）为 19.79（13.32），与 SGA 组的 21.4（13.4）相比（P=0.497），与足月 AGA 组的 27.70（13.96）相比（P=0.002）。母亲职业性烟草暴露导致脐瘦素显著下降（调整平均差异（95%CI）：-4.5ng/mL（-8.82，-0.19）；P=0.041）。