Healthy Gut Research Group, Center of Excellence in Functional Foods, National Agri-Food Biotechnology Institute (NABI), Knowledge City, Sector 81, SAS Nagar, Punjab 140306, India.
Food Funct. 2020 Nov 18;11(11):9833-9847. doi: 10.1039/d0fo01643h.
Finger millet (FM) and kodo millet (KM) are known for their multiple health benefits. Several studies have indicated the antioxidant and hypoglycemic potential of polyphenol rich extracts (PREs) from them. However, the protective roles of PREs from these millets in overcoming high-fat diet (HFD)-induced obesity have not yet been investigated. This study aimed to identify the polyphenols in FM-PREs and KM-PREs using HPLC-DAD/ESI-MS, and to evaluate the role of PREs in mitigating lipopolysaccharide induced inflammation in murine macrophage cells and in the reduction of HFD-induced metabolic complications using male Swiss albino mice. The results suggested that KM-PRE had higher polyphenol content than FM-PRE, of which taxifolin (98%) and catechin (86.6%) were the major fractions respectively. FM-PRE and KM-PRE prevented obesity, however, KM-PRE was more profound in preventing weight gain, adipose tissue hypertrophy, hepatic steatosis, and systemic inflammation than FM-PRE. This study suggests that FM-PRE and KM-PRE could be exploited for developing functional foods or nutraceuticals against obesity and comorbidities.
手指粟（FM）和科多粟（KM）以其多种健康益处而闻名。多项研究表明，多酚含量高的提取物（PREs）具有抗氧化和降血糖的潜力。然而，这些谷物的 PREs 克服高脂肪饮食（HFD）诱导的肥胖的保护作用尚未得到研究。本研究旨在使用 HPLC-DAD/ESI-MS 鉴定 FM-PREs 和 KM-PREs 中的多酚，并评估 PREs 在减轻脂多糖诱导的小鼠巨噬细胞炎症以及减少 HFD 诱导的代谢并发症方面的作用，研究对象为雄性瑞士白化小鼠。结果表明，KM-PRE 的多酚含量高于 FM-PRE，其中，税木黄酮（98%）和儿茶素（86.6%）分别是主要成分。FM-PRE 和 KM-PRE 都能预防肥胖，但与 FM-PRE 相比，KM-PRE 更能预防体重增加、脂肪组织肥大、肝脂肪变性和全身炎症。本研究表明，FM-PRE 和 KM-PRE 可用于开发功能性食品或营养保健品，以对抗肥胖和合并症。
