Yang Yun Sun, Jeong Eun Woo, Baek Youjin, Go Gwang-Woong, Lee Hyeon Gyu
Department of Food and Nutrition, Hanyang University, Seoul, 04763 Korea.
Food Sci Biotechnol. 2023 Jun 15;32(10):1415-1421. doi: 10.1007/s10068-023-01340-y. eCollection 2023 Sep.
Grains contain bioactive components that potentially have protective effects on chronic diseases such as diabetes. The anti-diabetic effects of blended grain ethanol extract (BGE) were evaluated in streptozotocin-nicotinamide (STZ-NA)-induced diabetic rats. BGE was prepared by mixing oat, sorghum, adzuki bean, finger millet, and proso millet (30:30:15:15:10). The rats were assigned into four groups, normal control, diabetic model control (DM), STZ-NA rats administered 200 mg/kg body weight (bw) of metformin, and STZ-NA rats administered 500 mg/kg bw of BGE (BGE). After 6 weeks of administration, the homeostatic model assessment of insulin resistance (12%) in BGE decreased compared to DM. Strikingly, the fasting blood glucose (23%) and oral glucose tolerance test (15%) were improved in BGE compared to DM. BGE also increased insulin immunoreactivities in pancreatic β-cells. In sum, BGE exhibits anti-hyperglycemic effects by improving fasting glucose levels and insulin secretion from pancreatic β-cells in the STZ-NA-induced diabetic rats.
谷物含有生物活性成分，可能对糖尿病等慢性疾病具有保护作用。在链脲佐菌素-烟酰胺（STZ-NA）诱导的糖尿病大鼠中评估了混合谷物乙醇提取物（BGE）的抗糖尿病作用。BGE通过将燕麦、高粱、赤小豆、黍和黍稷（30:30:15:15:10）混合制备而成。将大鼠分为四组：正常对照组、糖尿病模型对照组（DM）、给予200mg/kg体重二甲双胍的STZ-NA大鼠以及给予500mg/kg体重BGE的STZ-NA大鼠（BGE组）。给药6周后，与DM组相比，BGE组胰岛素抵抗的稳态模型评估值降低了12%。令人惊讶的是，与DM组相比，BGE组的空腹血糖水平降低了23%，口服葡萄糖耐量试验改善了15%。BGE还增加了胰腺β细胞中的胰岛素免疫反应性。总之，BGE通过改善STZ-NA诱导的糖尿病大鼠的空腹血糖水平和胰腺β细胞的胰岛素分泌，表现出降血糖作用。
