Dermatology Department, Complejo Hospitalario de Navarra, Pamplona, Spain.
Medical Oncology Department, Complejo Hospitalario de Navarra, Pamplona, Spain.
Eur J Cancer Care (Engl). 2021 Jan;30(1):e13344. doi: 10.1111/ecc.13344. Epub 2020 Oct 22.
To investigate the patterns of melanoma recurrence in the local population, including factors that may influence in this event and timing of relapse, and to determine the mode of detection of them.
This is a retrospective cohort study of patients with melanoma who underwent sentinel lymph node biopsy at the Complejo Hospitalario de Navarra (Spain) from 2002 to 2012. The following data were collected of each patient: age, gender, date of diagnosis, location of melanoma, histological subtype, Breslow thickness, ulceration, mitosis, sentinel node status, AJCC 8th edition stage, site of first diagnosed metastasis, mode of relapse, date of first relapse and time of death.
Of 308 patients, 30% people suffered metastasis. The mean follow-up time was 68.63 months. 51.1% of relapses were locoregional and 48.9% haemato-visceral. Sentinel node status was the only variable associated with higher risk of haemato-visceral metastasis (p < 0.001). The mean time between diagnosis of melanoma and recurrence was 2.7 years. Most recurrences were detected by the patient himself or had any type of symptoms and were consequently selected for a complementary test.
It is important to follow-up all patients with diagnosis of cutaneous melanoma, essentially during the first 5 years after diagnosis.
调查当地人群黑色素瘤复发的模式，包括可能影响该事件的因素和复发时间，并确定检测这些因素的方式。
这是一项对 2002 年至 2012 年间在纳瓦拉综合医院（西班牙）接受前哨淋巴结活检的黑色素瘤患者进行的回顾性队列研究。收集每位患者的以下数据：年龄、性别、诊断日期、黑色素瘤位置、组织学亚型、Breslow 厚度、溃疡、有丝分裂、前哨淋巴结状态、第 8 版 AJCC 分期、首次诊断转移部位、复发模式、首次复发日期和死亡日期。
在 308 名患者中，有 30%的人发生了转移。平均随访时间为 68.63 个月。51.1%的复发为局部区域复发，48.9%为血液-内脏转移。前哨淋巴结状态是唯一与更高风险的血液-内脏转移相关的变量（p<0.001）。从黑色素瘤诊断到复发的平均时间为 2.7 年。大多数复发是由患者自己发现或出现任何类型的症状，并因此选择进行补充检查。
对所有诊断为皮肤黑色素瘤的患者进行随访非常重要，尤其是在诊断后的前 5 年内。
