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肺结核患者中人类免疫缺陷病毒的流行率:一项横断面研究。

Prevalence of human immunodeficiency virus among pulmonary tuberculosis patients: A cross-sectional study.

机构信息

Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.

Department of Microbiology, Medicinal, Aromatic Plants and Traditional Medicine Research Institute (MAPTMRI), National Center for Research, Khartoum, Sudan.

出版信息

Microbiol Immunol. 2020 Dec;64(12):810-814. doi: 10.1111/1348-0421.12856. Epub 2020 Oct 29.

Abstract

Tuberculosis (TB) is caused by Mycobacterium tuberculosis and is an endemic disease in Sudan, where it has rapidly become the major complication of human immunodeficiency virus (HIV) infection. Thus, this study aimed to determine the prevalence of HIV among TB patients and evaluate the co-infection rate. The association of HIV prevalence with gender, age, and duration of treatment as risk factors was also determined. A descriptive cross-sectional study was performed in Omdurman Abu Anga Hospital, Khartoum, Sudan, from October 2018 to March 2019. A total of 281 blood samples were obtained randomly from pulmonary TB patients. The plasma was examined for the presence of HIV antibodies using sandwich ELISA. A structured questionnaire was used during data collection. A noticeable marker for HIV immunoglobulin M/immunoglobulin G was found in 12 patients (4.3%), of which five patients (41.7%) were diagnosed as new TB cases. Moreover, the relationship between age, sex, and duration of TB treatment and the prevalence of HIV was not significantly different (P > 0.05). In conclusion, the prevalence of HIV antibodies among TB pulmonary patients is high. Therefore, all TB patients should be examined for HIV risk factors and advised to undergo HIV testing. Further studies are essential to provide more insights into the epidemiology of the co-infection to better report the double burden of HIV and TB among TB patients in Sudan.

摘要

结核病(TB)是由结核分枝杆菌引起的,是苏丹的地方性疾病,在苏丹,结核病迅速成为人类免疫缺陷病毒(HIV)感染的主要并发症。因此,本研究旨在确定结核病患者中 HIV 的流行率,并评估合并感染率。还确定了 HIV 流行率与性别、年龄和治疗持续时间等危险因素的相关性。2018 年 10 月至 2019 年 3 月,在苏丹喀土穆的 Omdurman Abu Anga 医院进行了一项描述性横断面研究。从肺结核患者中随机抽取了 281 份血样。使用夹心 ELISA 法检测血浆中 HIV 抗体的存在。在数据收集过程中使用了结构化问卷。在 12 名患者(4.3%)中发现了 HIV 免疫球蛋白 M/免疫球蛋白 G 的明显标志物,其中 5 名患者(41.7%)被诊断为新的结核病病例。此外,年龄、性别和结核病治疗持续时间与 HIV 流行率之间的关系没有显著差异(P>0.05)。总之,肺结核患者中 HIV 抗体的流行率很高。因此,所有肺结核患者都应检查 HIV 危险因素,并建议进行 HIV 检测。需要进一步的研究来更深入地了解合并感染的流行病学,以便更好地报告苏丹肺结核患者中 HIV 和结核病的双重负担。

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