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John D. Loeser Award Lecture: Size does matter, but it isn't everything: the challenge of modest treatment effects in chronic pain clinical trials.

作者信息

Smith Shannon M, Fava Maurizio, Jensen Mark P, Mbowe Omar B, McDermott Michael P, Turk Dennis C, Dworkin Robert H

机构信息

Departments of Anesthesiology and Perioperative Medicine.

Obstetrics and Gynecology and.

出版信息

Pain. 2020 Sep;161 Suppl 1(1):S3-S13. doi: 10.1097/j.pain.0000000000001849.

DOI:10.1097/j.pain.0000000000001849
PMID:33090735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7434212/
Abstract
摘要

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A deeper look at pain variability and its relationship with the placebo response: results from a randomized, double-blind, placebo-controlled clinical trial of naproxen in osteoarthritis of the knee.深入探讨疼痛变异性及其与安慰剂反应的关系：来自萘普生治疗膝骨关节炎的随机、双盲、安慰剂对照临床试验的结果。
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2
Demonstrating Heterogeneity of Treatment Effects Among Patients: An Overlooked but Important Step Toward Precision Medicine.展示患者间治疗效果的异质性：迈向精准医学的被忽视但重要的一步。
Clin Pharmacol Ther. 2019 Jul;106(1):204-210. doi: 10.1002/cpt.1372. Epub 2019 Mar 12.
3
Clin Transl Sci. 2025 Feb;18(2):e70154. doi: 10.1111/cts.70154.
4
Treatment expectations and pain-related outcomes in clinical trials of digital cognitive-behavioral therapy for youth with chronic pain.针对患有慢性疼痛的青少年的数字认知行为疗法临床试验中的治疗期望和疼痛相关结果。
J Pain. 2025 Mar;28:104791. doi: 10.1016/j.jpain.2025.104791. Epub 2025 Jan 16.
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A systematic review and meta-analysis of randomized controlled head-to-head trials of recommended drugs for neuropathic pain.一项针对推荐用于神经性疼痛的药物的随机对照头对头试验的系统评价和荟萃分析。
Pain Rep. 2024 Feb 21;9(2):e1138. doi: 10.1097/PR9.0000000000001138. eCollection 2024 Apr.
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A randomized, placebo-controlled trial of long-acting dexamethasone viscous gel delivered by transforaminal injection for lumbosacral radicular pain.一项关于经椎间孔注射长效地塞米松粘性凝胶治疗腰骶神经根性疼痛的随机、安慰剂对照试验。
Pain. 2024 Dec 1;165(12):2762-2773. doi: 10.1097/j.pain.0000000000003287. Epub 2024 Jun 14.
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Depression and treatment with anti-calcitonin gene related peptide (CGRP) (ligand or receptor) antibodies for migraine.抑郁与抗降钙素基因相关肽（CGRP）（配体或受体）抗体治疗偏头痛。
Eur J Neurol. 2024 Feb;31(2):e16106. doi: 10.1111/ene.16106. Epub 2023 Oct 17.
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