Department of Ophthalmology, Keimyung University School of Medicine, 1095 Dalgebeol-daro, Dalseo-gu, Daegu, 42601, Republic of Korea.
Sci Rep. 2020 Oct 22;10(1):18111. doi: 10.1038/s41598-020-75151-0.
In preterm birth, the immature retina can develop a potentially blinding disorder of the eye known as retinopathy of prematurity (ROP). The vaso-proliferative phase of ROP begins at an approximate postmenstrual age (PMA) of 32 weeks. There is little or no evidence of an association between ROP development and retinal status in the early vaso-proliferative phase. We aimed to evaluate the retinal vascular findings of infants at 33-34 weeks PMA to determine their risk of ROP. We reviewed 130 serial wide-field retinal images from 65 preterm infants born before the gestational age of 31 weeks. ROP occurred more frequently in infants having a leading vascular edge within posterior Zone II. This was in contrast to normal infants, who are characterized by complete retinal vascularization up to Zone II at 34 weeks PMA. The probability of ROP development in preterm infants with retinal edge hemorrhage was 24.58 times higher than in preterm infants without retinal edge hemorrhage. Eyes with ROP that required treatment showed significantly delayed retinal vascularization accompanied by pre-plus disease. In conclusion, retinal status in the early vaso-proliferation phase might determine the risk of ROP.
在早产儿中，不成熟的视网膜可能会发展出一种称为早产儿视网膜病变（ROP）的潜在致盲眼病。ROP 的血管增生期大约始于孕龄 32 周。ROP 的发展与早期血管增生期视网膜状态之间几乎没有或没有关联的证据。我们旨在评估 33-34 周 PMA 时婴儿的视网膜血管发现，以确定他们患 ROP 的风险。我们回顾了 65 名胎龄小于 31 周的早产儿的 130 张连续广角视网膜图像。ROP 更常发生在具有后二区领先血管边缘的婴儿中。与正常婴儿形成对比，正常婴儿在 34 周 PMA 时视网膜血管化完整延伸到二区。视网膜边缘出血的早产儿发生 ROP 的可能性是没有视网膜边缘出血的早产儿的 24.58 倍。需要治疗的 ROP 眼显示视网膜血管化明显延迟，伴有前加病。总之，早期血管增生期的视网膜状态可能决定 ROP 的风险。
