Liu Shuai, Liu Lei, Ma Cui-Xia, Huang Liu-Hui, Li Bin
School of Information Science and Technology, University of Science and Technology of China, Hefei 230022, Anhui Province, China.
Eye Institute, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226006, Jiangsu Province, China.
Int J Ophthalmol. 2024 Aug 18;17(8):1453-1461. doi: 10.18240/ijo.2024.08.10. eCollection 2024.
To quantitatively assess the changes in mean vascular tortuosity (mVT) and mean vascular width (mVW) around the optic disc and their correlation with gestational age (GA) and birth weight (BW) in premature infants without retinopathy of prematurity (ROP).
A single-center retrospective study included a total of 133 (133 eyes) premature infants [mean corrected gestational age (CGA) 43.6wk] without ROP as the premature group and 130 (130 eyes) CGA-matched full-term infants as the control group. The peripapillary mVT and mVW were quantitatively measured using computer-assisted techniques.
Premature infants had significantly higher mVT (=0.0032) and lower mVW (=0.0086) by 2.68 (10 cm) and 1.85 µm, respectively. Subgroup analysis with GA showed significant differences (=0.0244) in mVT between the early preterm and middle to late preterm groups, but the differences between mVW were not significant (=0.6652). The results of the multiple linear regression model showed a significant negative correlation between GA and BW with mVT after adjusting sex and CGA (=0.0211 and =0.0006, respectively). For each day increase in GA at birth, mVT decreased by 0.1281 (10 cm) and for each 1 g increase in BW, mVT decreased by 0.006 (10 cm). However, GA (=0.9402) and BW (=0.7275) were not significantly correlated with mVW.
Preterm birth significantly affects the peripapillary vascular parameters that indicate higher mVT and narrower mVW in premature infants without ROP. Alterations in these parameters may provide new insights into the pathogenesis of ocular vascular disease.
定量评估无早产儿视网膜病变（ROP）的早产儿视盘周围平均血管迂曲度（mVT）和平均血管宽度（mVW）的变化及其与胎龄（GA）和出生体重（BW）的相关性。
一项单中心回顾性研究，共纳入133例（133只眼）无ROP的早产儿[平均矫正胎龄（CGA）43.6周]作为早产组，以及130例（130只眼）CGA匹配的足月儿作为对照组。使用计算机辅助技术定量测量视乳头周围的mVT和mVW。
早产儿的mVT（=0.0032）显著更高，mVW（=0.0086）显著更低，分别高出2.68（10 cm）和低1.85 µm。按GA进行亚组分析显示，极早早产组和中晚期早产组之间mVT存在显著差异（=0.0244），但mVW之间的差异不显著（=0.6652）。多元线性回归模型结果显示，在调整性别和CGA后，GA和BW与mVT之间存在显著负相关（分别为=0.0211和=0.0006）。出生时GA每增加一天，mVT降低0.1281（10 cm），BW每增加1 g，mVT降低0.006（10 cm）。然而，GA（=0.9402）和BW（=0.7275）与mVW无显著相关性。
早产显著影响视乳头周围血管参数，表明无ROP的早产儿mVT更高，mVW更窄。这些参数的改变可能为眼部血管疾病的发病机制提供新的见解。
