Jeon Mi Hye, Kang Taeuk, Yoo Sang Hoon, Swan Heather S, Kim Hyun Jung, Ahn Hyeong Sik
Department of Public Health, Graduate School, Korea University.
Division of Pulmonology, Department of Internal Medicine, College of Medicine, Daejeon St.Mary's Hospital, The Catholic University of Korea.
Sarcoidosis Vasc Diffuse Lung Dis. 2020;37(1):24-26. doi: 10.36141/svdld.v37i1.7660. Epub 2020 Mar 15.
Few national level, population-based studies are present on the epidemiology of sarcoidosis and it is unclear whether these patients have higher mortality than the general population. The objective of this study was to investigate the nationwide epidemiology, comorbidity and mortality in sarcoidosis in Korea.
For the period between 2008 to 2015, we used the national population-based database operated by Rare Intractable Disease registration program in which patients' diagnosis are based on uniform criteria. All sarcoidosis patients were identified and followed-up using the National Health Insurance database to determine their incidence, comorbidity, mortality, causes of death and standardised mortality ratio (SMR).
During the study period, we identified 3,259 new sarcoidosis patients. The average annual incidence was 0.81 per 100,000. The annual mortality rate was 9.26 per 1,000 person-years. The mortality rate were significantly higher than those of the general population (SMR 1.91, 95% confidence interval 1.62-2.25). The major comorbidities of sarcoidosis patients were the diseases of the respiratory system (17.64%), heart (5.43%), eyes (4.27%) and cancer (2.3%). Mortality was higher in patients with lung involvement. Of the 84 deaths identified in this study from 2008-2013, the most common cause of death was cancer (41.7%), followed by respiratory disease (13.1%), sarcoidosis (13.1%) and heart disease (8.3%).
We reported a nationwide incidence of sarcoidosis as 0.81 per 100,000 in Korea. The mortality of sarcoidosis patients was higher compared to the general population and the major causes of death were cancer, respiratory disease and sarcoidosis. Sarcoidosis patients with comorbid diseases showed increased mortality. .
关于结节病流行病学的全国性、基于人群的研究较少,目前尚不清楚这些患者的死亡率是否高于普通人群。本研究的目的是调查韩国结节病的全国流行病学、合并症及死亡率。
在2008年至2015年期间,我们使用了由罕见难治性疾病登记项目运营的全国性人群数据库,该数据库中患者的诊断基于统一标准。通过国家健康保险数据库识别并随访所有结节病患者,以确定其发病率、合并症、死亡率、死亡原因及标准化死亡率(SMR)。
在研究期间,我们共识别出3259例新的结节病患者。年平均发病率为每10万人0.81例。年死亡率为每1000人年9.26例。死亡率显著高于普通人群(标准化死亡率1.91,95%置信区间1.62 - 2.25)。结节病患者的主要合并症为呼吸系统疾病(17.64%)、心脏疾病(5.43%)、眼部疾病(4.27%)及癌症(2.3%)。肺部受累患者的死亡率更高。在本研究中,2008 - 2013年期间确定的84例死亡病例中,最常见的死亡原因是癌症(41.7%),其次是呼吸系统疾病(13.1%)、结节病(13.1%)和心脏病(8.3%)。
我们报告韩国结节病的全国发病率为每10万人0.81例。结节病患者的死亡率高于普通人群,主要死亡原因是癌症、呼吸系统疾病和结节病。患有合并症的结节病患者死亡率更高。