大麻二酚油相关的显微镜下结肠炎

Cannabidiol Oil-Associated Microscopic Colitis.

作者信息

Oruganti Poornima, Betcher Stephanie, Wakade Zuie, Ding Xianzhong, Abegunde Ayokunle T

机构信息

Internal Medicine, Loyola University Medical Center, Maywood, USA.

Gastroenterology, Loyola University Medical Center, Maywood, USA.

出版信息

Cureus. 2020 Sep 18;12(9):e10528. doi: 10.7759/cureus.10528.

DOI:10.7759/cureus.10528

PMID:33094069

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7574987/

Abstract

Microscopic colitis (MC) is a chronic inflammation condition of the colon characterized by watery diarrhea and normal appearing mucosa. A 75-year-old female presented with one-year history of chronic diarrhea while taking cannabidiol (CBD) for pain. Colonoscopy with random colon biopsies revealed collagenous colitis. She started budesonide and stopped CBD. At six-week follow-up, her diarrhea improved, and the budesonide dose was decreased. She restarted CBD oil twice but had diarrhea both times. Her diarrhea resolved after taking budesonide and stopping CBD. We report a case of CBD-associated MC to make clinicians aware of this potential adverse effect in patients who chronically use CBD.

摘要

显微镜下结肠炎（MC）是一种结肠的慢性炎症性疾病，其特征为水样腹泻且黏膜外观正常。一名75岁女性在服用大麻二酚（CBD）止痛时有1年慢性腹泻病史。结肠镜检查及随机结肠活检显示为胶原性结肠炎。她开始使用布地奈德并停用CBD。在6周随访时，她的腹泻有所改善，布地奈德剂量减少。她两次重新开始使用CBD油，但两次均出现腹泻。在服用布地奈德并停用CBD后，她的腹泻得到缓解。我们报告一例与CBD相关的MC病例，以让临床医生意识到长期使用CBD的患者可能出现这种不良反应。