Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Korea.
Chembiochem. 2021 Jan 15;22(2):319-325. doi: 10.1002/cbic.202000583. Epub 2020 Oct 23.
Protein phosphorylation is one of the most studied post-translational modifications (PTMs). Despite the remarkable advances in phosphoproteomics, a chemically less-stable subset of the phosphosites, which we call the crypto-phosphoproteome, has remained underexplored due to technological challenges. In this Viewpoint, we briefly summarize the current understanding of these elusive protein phosphorylations and identify the missing pieces for future studies.
蛋白质磷酸化是最受研究的翻译后修饰（PTMs）之一。尽管磷酸蛋白质组学取得了显著进展，但由于技术挑战，我们称之为隐匿磷酸蛋白质组的化学稳定性较低的磷酸化位点亚组仍未得到充分探索。在本观点中，我们简要总结了对这些难以捉摸的蛋白质磷酸化的现有理解，并确定了未来研究的缺失环节。
