INSERM U1195, Le Kremlin-Bicêtre, France.
Centre Hospitalier Intercommunal de Créteil, Créteil, France.
Leuk Lymphoma. 2021 Feb;62(2):300-307. doi: 10.1080/10428194.2020.1834090. Epub 2020 Oct 23.
Peripheral lymphopenia is a well-known negative prognostic marker in classical Hodgkin lymphoma (cHL). We characterized the peripheral B-cell compartment in a prospective cohort of 83 pediatric cHL patients. We observed significantly low total B-cell counts (<100 cells/µl) in 31 of 83 patients (37%). More specifically, there was a smaller peripheral IgDCD27 naïve B-cell pool among B-cell lymphopenic patients than for non-B-cell lymphopenic patients ( < 0.01). The B-cell count was lower in patients without Epstein Barr Virus EBV) expression than among those with EBV expression ( = 0.03). Peripheral B-cell lymphopenia was associated with the presence of poor prognostic features, such as advanced lymphoma stage ( < 0.01) and the presence of B symptoms ( = 0.04). Of interest, B-cell lymphopenia resolved in all six studied patients in long-term remission. Our findings support that cHL tumor-associated factors interfere with the distribution of peripheral B-cell subsets.
外周血淋巴细胞减少是经典型霍奇金淋巴瘤（cHL）的一个众所周知的预后不良标志物。我们对 83 例儿科 cHL 患者的前瞻性队列进行了外周 B 细胞区室特征分析。我们观察到 83 例患者中有 31 例（37%）存在显著的总 B 细胞计数降低（<100 个细胞/μl）。更具体地说，与非 B 细胞淋巴细胞减少症患者相比，B 细胞淋巴细胞减少症患者的外周 IgDCD27 幼稚 B 细胞池较小（<0.01）。无 EBV 表达的患者的 B 细胞计数低于 EBV 表达的患者（=0.03）。外周 B 细胞减少症与预后不良的特征有关，如晚期淋巴瘤分期（<0.01）和 B 症状的存在（=0.04）。有趣的是，在长期缓解的 6 名研究患者中，B 细胞减少症均得到缓解。我们的研究结果表明，cHL 肿瘤相关因素会干扰外周 B 细胞亚群的分布。
