肿瘤干细胞与靶向药物递送策略。
Cancer stem cells and strategies for targeted drug delivery.
机构信息
School of Pharmacy, Jiangsu University, Zhenjiang, 212013, Jiangsu, China.
College of Pharmacy, University of Minnesota, Minneapolis, MN, 55455, USA.
出版信息
Drug Deliv Transl Res. 2021 Oct;11(5):1779-1805. doi: 10.1007/s13346-020-00863-9. Epub 2020 Oct 23.
Abstract
Cancer stem cells (CSCs) are a small proportion of cancer cells with high tumorigenic activity, self-renewal ability, and multilineage differentiation potential. Standard anti-tumor therapies including conventional chemotherapy, radiation therapy, and molecularly targeted therapies are not effective against CSCs, and often lead to enrichment of CSCs that can result in tumor relapse. Therefore, it is hypothesized that targeting CSCs is key to increasing the efficacy of cancer therapies. In this review, CSC properties including CSC markers, their role in tumor growth, invasiveness, metastasis, and drug resistance, as well as CSC microenvironment are discussed. Further, CSC-targeted strategies including the use of targeted drug delivery systems are examined.
摘要
癌症干细胞（CSCs）是一小部分具有高肿瘤发生活性、自我更新能力和多谱系分化潜能的癌细胞。标准的抗肿瘤疗法，包括常规化疗、放疗和分子靶向治疗，对 CSCs 无效，而且往往导致 CSCs 的富集，从而导致肿瘤复发。因此，有人假设针对 CSCs 是提高癌症治疗效果的关键。在这篇综述中，讨论了 CSC 的特性，包括 CSC 标志物、它们在肿瘤生长、侵袭、转移和耐药性中的作用，以及 CSC 微环境。此外，还研究了针对 CSC 的策略，包括使用靶向药物传递系统。
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