Institut Necker-Enfants Malades (INEM), Inserm U1151-CNRS UMR 8253, F-75993, Paris, France.
Université Paris Descartes-Sorbonne Paris Cité, F-75993, Paris, France.
Mol Cancer. 2020 Feb 6;19(1):27. doi: 10.1186/s12943-019-1126-8.
Cancer is now considered as a heterogeneous ecosystem in which tumor cells collaborate with each other and with host cells in their microenvironment. As circumstances change, the ecosystem evolves to ensure the survival and growth of the cancer cells. In this ecosystem, metabolism is not only a key player but also drives stemness. In this review, we first summarize our current understanding of how autophagy influences cancer stem cell phenotype. We emphasize metabolic pathways in cancer stem cells and discuss how autophagy-mediated regulation metabolism is involved in their maintenance and proliferation. We then provide an update on the role of metabolic reprogramming and plasticity in cancer stem cells. Finally, we discuss how metabolic pathways in cancer stem cells could be therapeutically targeted.
癌症现在被认为是一个异质的生态系统，其中肿瘤细胞相互协作，并与微环境中的宿主细胞相互协作。随着环境的变化，这个生态系统会不断进化，以确保癌细胞的生存和生长。在这个生态系统中，代谢不仅是一个关键因素，而且还驱动着肿瘤干细胞的干性。在这篇综述中，我们首先总结了我们目前对自噬如何影响肿瘤干细胞表型的理解。我们强调了肿瘤干细胞中的代谢途径，并讨论了自噬介导的代谢调节如何参与它们的维持和增殖。然后，我们提供了关于代谢重编程和可塑性在肿瘤干细胞中的作用的最新信息。最后，我们讨论了如何针对肿瘤干细胞中的代谢途径进行治疗。
