Department of Neurology, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu, China.
BMC Neurol. 2020 Oct 23;20(1):386. doi: 10.1186/s12883-020-01962-3.
In this study, we report a case of a young female who was hospitalized for seizures and diagnosed with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.
The main feature of this patient was bilateral temporal calcifications detected by routine head computed tomography (CT). The co-existence of anti-NMDAR encephalitis and cerebral calcifications has not been reported. We supposed that the patient had an incomplete form of celiac disease (CD), epilepsy and cerebral calcifications syndrome (CEC). The patient's symptoms were alleviated by a series of treatments, and she remained stable during the follow-ups.
Our findings confirm the rarity co-existing anti-NMDAR encephalitis and cerebral calcifications. In future clinical work, we need to elucidate the relationship between anti-NMDAR encephalitis and cerebral calcifications, and the association between anti-NMDAR encephalitis and other co-existing autoimmune disorders.
本研究报告了一例年轻女性癫痫发作住院，被诊断为抗 N-甲基-D-天冬氨酸受体（NMDAR）脑炎。
该患者的主要特征是常规头部计算机断层扫描（CT）显示双侧颞叶钙化。抗 NMDAR 脑炎和脑钙化共存尚未报道。我们推测该患者患有不完全型乳糜泻（CD）、癫痫和脑钙化综合征（CEC）。该患者经一系列治疗后症状缓解，随访期间病情稳定。
我们的发现证实了抗 NMDAR 脑炎和脑钙化罕见共存。在未来的临床工作中，我们需要阐明抗 NMDAR 脑炎和脑钙化之间的关系，以及抗 NMDAR 脑炎与其他共存自身免疫性疾病之间的关系。
