Thude Hansjörg, Tiede Petra, Sterneck Martina, Peine Sven, Nashan Björn, Koch Martina
University Medical Center Hamburg-Eppendorf, Institute of Transfusion Medicine, Martinistraße 52, 20246 Hamburg, Germany.
University Medical Center Hamburg-Eppendorf, Institute of Transfusion Medicine, Martinistraße 52, 20246 Hamburg, Germany.
Hum Immunol. 2020 Dec;81(12):675-678. doi: 10.1016/j.humimm.2020.10.002. Epub 2020 Oct 20.
The co-stimulatory molecule CD28 plays an important role in T-cell-mediated immune response like acute cellular liver transplant rejection. The aim of the retrospective case- control study was to examine whether the single nucleotide polymorphisms (SNPs) rs3116487, rs3116494, and rs3116496 of the CD28 gene are associated with acute cellular liver transplant rejection. The mentioned SNPs were genotyped in 147 liver transplant recipients without acute cellular rejection and 144 liver transplant recipients with acute cellular rejection by real-time endpoint genotyping. The genotype and allele frequencies of the SNPs did not show any significant differences between both groups. Haplotype analyzes of the SNPs also showed no association. Our data suggest that the analyzed SNPs are not major contributors to the susceptibility of acute cellular liver transplant rejection.
共刺激分子CD28在T细胞介导的免疫反应中发挥重要作用，如急性细胞性肝移植排斥反应。这项回顾性病例对照研究的目的是检验CD28基因的单核苷酸多态性（SNP）rs3116487、rs3116494和rs3116496是否与急性细胞性肝移植排斥反应相关。通过实时终点基因分型对147例无急性细胞排斥反应的肝移植受者和144例有急性细胞排斥反应的肝移植受者进行上述SNP的基因分型。两组之间SNP的基因型和等位基因频率没有显示出任何显著差异。SNP的单倍型分析也未显示出相关性。我们的数据表明，所分析的SNP不是急性细胞性肝移植排斥反应易感性的主要因素。
