Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Respir Investig. 2021 Jan;59(1):145-148. doi: 10.1016/j.resinv.2020.08.009. Epub 2020 Oct 21.
Pulmonary diffusing capacity for carbon monoxide (DL) is a valuable pulmonary function test to evaluate the gas exchange capacity of the lungs. Generally, DL values are significantly lower in patients with chronic obstructive pulmonary disease (COPD), particularly in those with a predominantly emphysema phenotype. However, it is extremely rare that DL values cannot be obtained for reasons other than technical errors. Herein, we report two patients with COPD in whom DL values were undetectable without prolonging the breath-holding time for the test. We discuss possible mechanisms for these peculiar findings.
肺一氧化碳弥散量（DL）是评估肺部气体交换能力的一项有价值的肺功能测试。一般来说，慢性阻塞性肺疾病（COPD）患者的 DL 值明显较低，特别是以肺气肿表型为主的患者。然而，由于技术错误以外的其他原因而无法获得 DL 值的情况极为罕见。在此，我们报告了两例 COPD 患者，他们在不延长试验屏息时间的情况下，DL 值无法检测到。我们讨论了这些特殊发现的可能机制。
