G6PD：癌症中代谢重编程和氧化还原信号的枢纽。
G6PD: A hub for metabolic reprogramming and redox signaling in cancer.
机构信息
Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technology, Hsinchu, Taiwan.
New York University School of Medicine, New York, NY, USA.
出版信息
Biomed J. 2021 Jun;44(3):285-292. doi: 10.1016/j.bj.2020.08.001. Epub 2020 Aug 7.
Abstract
Metabolic hubs play a major role in the initiation and development of cancer. Oncogenic signaling pathways drive metabolic reprogramming and alter redox homeostasis. G6PD has potential oncogenic activity and it plays a pivotal role in cell proliferation, survival and stress responses. Aberrant activation of G6PD via metabolic reprogramming alters NADPH levels, leading to an antioxidant or a pro-oxidant environment which can either enhance DNA oxidative damage and genomic instability or initiate oncogenic signaling. Nutrient deprivation can rewire metabolism, which leads to mutations that determine a cancer cell's fate. Deregulated G6PD status and oxidative stress form a vicious cycle, which paves the way for cancer progression. This review aims to update and focus the potential role of G6PD in metabolic reprogramming and redox signaling in cancer.
摘要
代谢枢纽在癌症的发生和发展中起着重要作用。致癌信号通路驱动代谢重编程并改变氧化还原稳态。G6PD 具有潜在的致癌活性，它在细胞增殖、存活和应激反应中起着关键作用。通过代谢重编程异常激活 G6PD 会改变 NADPH 水平，导致抗氧化或促氧化剂环境，从而增强 DNA 氧化损伤和基因组不稳定性，或启动致癌信号。营养剥夺可以重新布线代谢，导致突变，从而决定癌细胞的命运。G6PD 状态失调和氧化应激形成恶性循环，为癌症进展铺平道路。本综述旨在更新和关注 G6PD 在癌症代谢重编程和氧化还原信号中的潜在作用。
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