Zheng Zhuomeng, Xiao Peiyao, Kuang Jiale, Wang Zhiyu, Wang Xinyu, Huang Da, Guo Yuxuan, Zhou Li, Yang Yiyuan, Ding Siyu, Zheng Chanjuan, Wang Yian, Fu Shujun, Deng Xiyun
Key Laboratory of Translational Cancer Stem Cell Research, Department of Pathophysiology, School of Basic Medical Sciences, Hunan Normal University, Changsha, Hunan 410013, China.
J Cancer. 2025 Jan 1;16(3):821-834. doi: 10.7150/jca.105849. eCollection 2025.
Lysine succinylation is an emerging post-translational modification of proteins. It involves the addition of the succinyl group to lysine residues of target proteins through both enzymatic and non-enzymatic pathways. This modification can alter the structure of the target protein, which, in turn, impacts protein activity and function and is involved in a wide range of diseases. In the field of cancer biology, lysine succinylation has been shown to exert a substantial influence on metabolic reprogramming of tumor cells, regulation of gene expression, and activation of oncogenic signaling pathways. Furthermore, lysine succinylation modulates the activity of immune cells, thereby affecting the immune evasion of tumor cells. Notably, researchers are currently developing inhibitors and activators of lysine succinylation which can inhibit tumor cell proliferation, migration, and metastasis, with potential usefulness in future clinical practice. This article provides an overview of the biological functions of lysine succinylation in cancer and its potential applications in cancer treatment, offering a novel perspective for future cancer management.
赖氨酸琥珀酰化是一种新出现的蛋白质翻译后修饰。它涉及通过酶促和非酶促途径将琥珀酰基团添加到靶蛋白的赖氨酸残基上。这种修饰可以改变靶蛋白的结构，进而影响蛋白质的活性和功能，并与多种疾病有关。在癌症生物学领域，赖氨酸琥珀酰化已被证明对肿瘤细胞的代谢重编程、基因表达调控和致癌信号通路的激活有重大影响。此外，赖氨酸琥珀酰化调节免疫细胞的活性，从而影响肿瘤细胞的免疫逃逸。值得注意的是，研究人员目前正在开发赖氨酸琥珀酰化的抑制剂和激活剂，它们可以抑制肿瘤细胞的增殖、迁移和转移，在未来临床实践中具有潜在的应用价值。本文综述了赖氨酸琥珀酰化在癌症中的生物学功能及其在癌症治疗中的潜在应用，为未来癌症管理提供了新的视角。
