Martin N F, Stark W J, Maumenee A E
Wilmer Institute, Johns Hopkins Hospital, Baltimore, Maryland 21205.
Ophthalmic Surg. 1987 Aug;18(8):564-9.
Three cases of Mooren's ulcer (four eyes) and one case of marginal corneal ulcer associated with relapsing polychondritis (two eyes) are presented with decrease in ocular inflammation following extensive lamellar keratectomy or lamellar keratoplasty. Tissue adhesive was needed in two cases to maintain ocular integrity. The procedure may work by the removal of a corneal antigenic stimulus to a self-perpetrating auto-immune phenomenon that causes corneal melting. More cases are needed to evaluate the therapeutic efficacy of lamellar keratectomy for Mooren's and Mooren's-like corneal ulcers.
本文报告了3例蚕蚀性角膜溃疡(4只眼)和1例与复发性多软骨炎相关的边缘性角膜溃疡(2只眼),在进行广泛板层角膜切除术或板层角膜移植术后,眼部炎症减轻。2例需要使用组织黏合剂来维持眼球完整性。该手术可能通过去除角膜抗原刺激来发挥作用,这种抗原刺激会引发导致角膜溶解的自身免疫现象。需要更多病例来评估板层角膜切除术对蚕蚀性和类蚕蚀性角膜溃疡的治疗效果。