Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, 8001, Zurich, Switzerland.
Population Health Laboratory (#PopHealthLab), University of Fribourg, Fribourg, Switzerland.
Int J Public Health. 2020 Dec;65(9):1529-1548. doi: 10.1007/s00038-020-01494-0. Epub 2020 Oct 24.
Seroprevalence studies to assess the spread of SARS-CoV-2 infection in the general population and subgroups are key for evaluating mitigation and vaccination policies and for understanding the spread of the disease both on the national level and for comparison with the international community.
Corona Immunitas is a research program of coordinated, population-based, seroprevalence studies implemented by Swiss School of Public Health (SSPH+). Over 28,340 participants, randomly selected and age-stratified, with some regional specificities will be included. Additional studies in vulnerable and highly exposed subpopulations are also planned. The studies will assess population immunological status during the pandemic.
Phase one (first wave of pandemic) estimates from Geneva showed a steady increase in seroprevalence up to 10.8% (95% CI 8.2-13.9, n = 775) by May 9, 2020. Since June, Zurich, Lausanne, Basel City/Land, Ticino, and Fribourg recruited a total of 5973 participants for phase two thus far.
Corona Immunitas will generate reliable, comparable, and high-quality serological and epidemiological data with extensive coverage of Switzerland and of several subpopulations, informing health policies and decision making in both economic and societal sectors. ISRCTN Registry: https://www.isrctn.com/ISRCTN18181860 .
评估 SARS-CoV-2 感染在普通人群和亚组中的传播情况的血清流行率研究，对于评估缓解和疫苗接种政策、了解疾病在国家层面和国际社会的传播情况至关重要。
“冠状病毒免疫研究”（Corona Immunitas）是由瑞士公共卫生学院（SSPH+）实施的一项协调的、基于人群的血清流行率研究计划。将纳入 28340 多名随机选择且按年龄分层的参与者，同时具有一些区域性特点。还计划对弱势和高度暴露的亚人群进行额外的研究。这些研究将评估大流行期间人群的免疫状况。
第一阶段（大流行的第一波）来自日内瓦的估计显示，血清阳性率稳步上升，截至 2020 年 5 月 9 日达到 10.8%（95%CI 8.2-13.9，n=775）。自 6 月以来，苏黎世、洛桑、巴塞尔市/州、提契诺州和弗里堡共招募了 5973 名参与者进行第二阶段研究。
“冠状病毒免疫研究”将生成可靠、可比和高质量的血清学和流行病学数据，广泛覆盖瑞士和多个亚人群，为经济和社会部门的卫生政策和决策提供信息。ISRCTN 注册：https://www.isrctn.com/ISRCTN18181860。
