Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland
Department of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
BMJ Open. 2022 Jan 31;12(1):e055515. doi: 10.1136/bmjopen-2021-055515.
The COVID-19 pandemic has affected billions of people around the world both directly through the infection itself and indirectly through its economic, social and sanitary impact. Collecting data over time is essential for the understanding of the disease spread, the incidence of COVID-19-like symptoms, the level and dynamics of immunity, as well as the long-term impact of the pandemic. The objective of the study was to set up a longitudinal follow-up of adult participants of serosurveys carried out in the canton of Geneva, Switzerland, during the COVID-19 pandemic. This follow-up aims at monitoring COVID-19 related symptoms and SARS-CoV-2 seroconversion, as well as the overall impact of the pandemic on several dimensions of health and on socioeconomic factors over a period of at least 2 years.
Serosurvey participants were invited to create an account on the dedicated digital platform Specchio-COVID19 (https://www.specchio-covid19.ch/). On registration, an initial questionnaire assessed sociodemographic and lifestyle characteristics (including housing conditions, physical activity, diet, alcohol and tobacco consumption), anthropometry, general health and experience related to COVID-19 (symptoms, COVID-19 test results, quarantines, hospitalisations). Weekly, participants were invited to fill in a short questionnaire with updates on self-reported COVID-19-compatible symptoms, SARS-CoV-2 infection testing and vaccination. A more detailed questionnaire about mental health, well-being, risk perception and changes in working conditions was proposed monthly. Supplementary questionnaires were proposed at regular intervals to assess more in depth the impact of the pandemic on physical and mental health, vaccination adherence, healthcare consumption and changes in health behaviours. At baseline, serology testing allowed to assess the spread of SARS-CoV-2 infection among the general population and subgroups of workers. Additionally, seropositive participants and a sample of randomly selected participants were invited for serologic testing at regular intervals in order to monitor both the seropersistance of anti-SARS-CoV-2 antibodies and the seroprevalence of anti-SARS-CoV-2 antibodies in the population of the canton of Geneva.
The study was approved by the Cantonal Research Ethics Commission of Geneva, Switzerland (CCER Project ID 2020-00881). Results will be disseminated in a variety of ways, via the Specchio-COVID-19 platform, social media posts, press releases and through regular scientific dissemination methods (open-access articles, conferences).
COVID-19 大流行直接通过感染本身，间接通过其经济、社会和卫生影响，影响了全球数十亿人。随着时间的推移收集数据对于了解疾病传播、COVID-19 样症状的发生率、免疫水平和动态以及大流行的长期影响至关重要。本研究的目的是建立对瑞士日内瓦州 COVID-19 大流行期间进行的血清学调查的成年参与者的纵向随访。该随访旨在监测与 COVID-19 相关的症状和 SARS-CoV-2 血清转化，以及大流行对健康和社会经济因素的多个方面的总体影响，至少持续 2 年。
血清学调查参与者被邀请在专门的数字平台 Specchio-COVID19（https://www.specchio-covid19.ch/）上创建一个账户。在注册时，初始问卷评估了社会人口统计学和生活方式特征（包括住房条件、身体活动、饮食、酒精和烟草消费）、人体测量学、一般健康状况以及与 COVID-19 相关的经历（症状、COVID-19 检测结果、隔离、住院）。每周，参与者都会被邀请填写一份简短问卷，更新自我报告的 COVID-19 相容症状、SARS-CoV-2 感染检测和疫苗接种情况。每月都会提出更详细的关于心理健康、幸福感、风险感知和工作条件变化的问卷。定期提出补充问卷，以更深入地评估大流行对身心健康、疫苗接种依从性、医疗保健消费和健康行为变化的影响。在基线时，血清学检测允许评估 SARS-CoV-2 感染在一般人群和工人亚组中的传播情况。此外，血清阳性参与者和随机选择的参与者样本被邀请定期进行血清学检测，以监测抗 SARS-CoV-2 抗体的血清持久性和日内瓦州人群中抗 SARS-CoV-2 抗体的血清流行率。
该研究得到了瑞士日内瓦州研究伦理委员会的批准（CCER 项目 ID 2020-00881）。结果将通过多种方式传播，包括 Specchio-COVID-19 平台、社交媒体帖子、新闻稿以及通过定期的科学传播方法（开放获取文章、会议）。
