N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russian Federation, Moscow, Russia.
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Bull Exp Biol Med. 2020 Oct;169(6):806-810. doi: 10.1007/s10517-020-04985-5. Epub 2020 Oct 24.
Prognosis for some histological variants of a rare breast disease, phyllodes tumors, is evaluated. The prognostic potential of some molecular biological factors significantly correlating with breast cancer prognosis is evaluated on a unique clinical material (244 cases with benign, intermediate, and malignant phyllodes tumors). The development of benign phyllodes tumor relapse directly correlated with the number of G0/1-phase cells and inversely correlated with the number of cells in the G2+M and S phases. The level of steroid hormone receptors in phyllodes tumors cannot serve as a prognostic marker predicting the disease course. The presence of somatic mutations of TP53 gene and loss of heterozygosity of specific intragenic loci in the tumor correlate with the development of disease relapse (p<0.05).
评估了一种罕见乳腺疾病叶状肿瘤的某些组织学变异型的预后。在独特的临床资料（244 例良性、中间型和恶性叶状肿瘤）上评估了一些与乳腺癌预后显著相关的分子生物学因素的预后潜力。良性叶状肿瘤复发的发展与 G0/1 期细胞的数量直接相关，与 G2+M 和 S 期细胞的数量成反比。叶状肿瘤中甾体激素受体的水平不能作为预测疾病过程的预后标志物。TP53 基因突变和肿瘤中特定基因内位点的杂合性丢失的存在与疾病复发的发展相关（p<0.05）。
