鉴定结构和神经保护活性的木脂素从花蕾的 Pamp.

Structural elucidation and neuroprotective activities of lignans from the flower buds of Pamp.

机构信息

Key Laboratory of Modern Preparation of TCM of Ministry of Education, Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.

College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China.

出版信息

Z Naturforsch C J Biosci. 2020 Oct 26;76(3-4):147-152. doi: 10.1515/znc-2020-0100. Print 2021 Mar 26.

DOI:10.1515/znc-2020-0100

PMID:33098637

Abstract

Two new lignans, 3,4-(10-methoxy-phenylallyl)-9″-((10'-isopropanol-3',4'-furan)-phenylacetyl)-8″-dioxane-7″-O--d-glucopyranoside (), 3,4-benzolactone-9″-((12'-isopropanol-3',4'-furan)-phenylbutenone)-8″-dioxane-7″-O--d-glucopyranoside (), and nine known lignan derivatives (-) were isolated from the flower buds of Pamp. for the first time. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS data, as well as by comparison with those of the references. Compounds (-) were evaluated for their neuroprotective activities against 6-OHDA-induced cell death in SH-SY5Y cells. As a result, compounds , , and exhibited significant neuroprotective activities with IC values in the range of 3.08-6.12 μM.

摘要

从黄花倒水莲的花蕾中首次分离得到两种新的木脂素

3,4-(10-甲氧基-苯丙基)-9″-((10'-异丙醇-3',4'-呋喃)-苯甲酰基)-8″-二氧杂环己烷-7″-O--d-吡喃葡萄糖苷（）和 3,4-苯并内酯-9″-((12'-异丙醇-3',4'-呋喃)-苯丁烯酮)-8″-二氧杂环己烷-7″-O--d-吡喃葡萄糖苷（），以及另外 9 种已知的木脂素衍生物。通过 1D 和 2D NMR、UV、IR 和 MS 数据以及与参考文献的比较，确定了它们的结构。对这些化合物进行了抗 6-OHDA 诱导的 SH-SY5Y 细胞死亡的神经保护活性评价。结果表明，化合物、和表现出显著的神经保护活性，IC 值范围为 3.08-6.12 μM。