Nguyen Thi Tuyet Mai, Lee Hyun-Su, Nguyen Thi Thu, Ngo Thi Quynh Mai, Jun Chang-Duk, Min Byung Sun, Kim Jeong Ah
College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University.
College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu.
Chem Pharm Bull (Tokyo). 2017;65(9):840-847. doi: 10.1248/cpb.c17-00314.
Four new lignans, a furofuran lignan medioresinol B (10) and three tetrahydrofuran lignans kobusinol C (16), 7'-methoxy magnostellin A (21), and mangnostellin D (23), along with 19 known lignans, were isolated from the flower buds of Magnolia biondii PAMP. The structures of the isolates were elucidated using spectroscopic analysis, mainly one- and two-dimensional NMR, high resolution-MS, and circular dichroism techniques as well as Mosher's esterification method. The anti-allergic effects of the isolated compounds were evaluated by analyzing the inhibition of interleukin-2 (IL-2) expression in Jurkat T-cells. Compounds 11-14 reduced IL-2 expression in a dose-dependent manner.
从望春玉兰（Magnolia biondii PAMP）的花芽中分离出4个新木脂素，即1个呋喃骈呋喃木脂素medioresinol B（10）和3个四氢呋喃木脂素kobusinol C（16）、7'-甲氧基magnostellin A（21）以及mangnostellin D（23），同时还分离出19个已知木脂素。通过光谱分析，主要是一维和二维核磁共振、高分辨质谱、圆二色光谱技术以及莫舍尔酯化法对分离得到的化合物结构进行了鉴定。通过分析对Jurkat T细胞中白细胞介素-2（IL-2）表达的抑制作用来评估分离得到的化合物的抗过敏作用。化合物11 - 14以剂量依赖的方式降低了IL-2的表达。
