Total healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Bone. 2021 Jan;142:115690. doi: 10.1016/j.bone.2020.115690. Epub 2020 Oct 21.
PURPOSE/INTRODUCTION: Conflicting results have been published regarding the effect of abnormal glucose metabolism on osteoporosis (AGM). Fasting glucose is a reliable indicator for abnormal glucose metabolism. Therefore, the aim of present study is to identify the association of fasting glucose level with the risk of incident osteoporosis.
In a cohort of 59,936 men and 36,690 women (mean age of 63.9 ± 7.1 years) registered in national health insurance database, we assessed the risk of incident osteoporosis according to the quartile levels of baseline fasting glucose (quartile 1: <88 mg/dL, quartile 2: 88-96 mg/dL, quartile 3: 97-107 mg/dL and quartile 4: ≥108 mg/dL) and glycemic status categorized into normal, impaired fasting glucose (IFG) and diabetes mellitus (DM). Multivariate Cox-proportional hazard model was used in calculating adjusted hazard ratios (HRs) and 95% confidence interval (CI) for incident osteoporosis (adjusted HRs [95% CI]).
Compared with first quartile (reference), the risk of osteoporosis significantly decreased above the fourth quartile in men (second quartile: 1.04 [0.91-1.18], third quartile: 0.88 (0.76-1.00) and fourth quartile: 0.80 [0.70-0.92]) and above third quartile in women (second quartile: 0.95 [0.90-1.01], third quartile: 0.91 [0.86-0.97] and fourth quartile: 0.82 [0.77-0.88]). The risk of osteoporosis was less associated with IFG (men: 0.84 [0.76-0.94] and women: 0.93 [0.89-0.98]) and DM (men: 0.77 [0.65-0.91] and women: 0.75 [0.69-0.81]) than normal glucose group in both men and women.
Our results suggest that elevated fasting glucose potentially associated with the decreased risk of osteoporosis.
MINI-ABSTRACT: This retrospective study investigated the association between fasting glucose level and incidence of osteoporosis. Our findings indicate that elevated fasting glucose is significantly associated with the decreased risk of osteoporosis.
目的/引言：关于异常葡萄糖代谢对骨质疏松症（AGM）的影响，已有相互矛盾的结果发表。空腹血糖是异常葡萄糖代谢的可靠指标。因此，本研究的目的是确定空腹血糖水平与骨质疏松症发病风险的关系。
在国家健康保险数据库中登记的 59936 名男性和 36690 名女性（平均年龄 63.9±7.1 岁）的队列中，我们根据基线空腹血糖的四分位水平（第 1 四分位：<88mg/dL，第 2 四分位：88-96mg/dL，第 3 四分位：97-107mg/dL，第 4 四分位：≥108mg/dL）和血糖状态（分为正常、空腹血糖受损（IFG）和糖尿病（DM））评估骨质疏松症发病的风险。使用多变量 Cox 比例风险模型计算骨质疏松症发病的调整后危险比（HRs）和 95%置信区间（95%CI）（调整后 HRs[95%CI]）。
与第 1 四分位（参考）相比，男性中空腹血糖高于第 4 四分位时（第 2 四分位：1.04[0.91-1.18]，第 3 四分位：0.88[0.76-1.00]，第 4 四分位：0.80[0.70-0.92]），女性中空腹血糖高于第 3 四分位时（第 2 四分位：0.95[0.90-1.01]，第 3 四分位：0.91[0.86-0.97]，第 4 四分位：0.82[0.77-0.88]），骨质疏松症发病风险显著降低。IFG（男性：0.84[0.76-0.94]和女性：0.93[0.89-0.98]）和 DM（男性：0.77[0.65-0.91]和女性：0.75[0.69-0.81]）与正常葡萄糖组相比，骨质疏松症发病风险较低。
我们的结果表明，空腹血糖升高可能与骨质疏松症发病风险降低有关。
