Center for Practice Changing Research, Ottawa Hospital Research Institute, The Ottawa Hospital, General Campus, 501 Smyth Road, Box 201b, Ottawa, Ontario, K1H 8 L6, Canada.
Substance Use and Concurrent Disorders Program, The Royal Ottawa Mental Health Centre, Ottawa, Ontario, Canada.
Syst Rev. 2020 Oct 24;9(1):245. doi: 10.1186/s13643-020-01499-z.
Methamphetamine use and harms are rising rapidly. Management of patients with methamphetamine use disorder (MUD) and problematic methamphetamine use (PMU) is challenging, with no clearly established best approach; both psychosocial and pharmacologic interventions have been described. Furthermore, given the diversity of individuals that use methamphetamines, there is a need to assess evidence for treatments for subgroups including youths; gay, bisexual, and other men who have sex with men; individuals with mental health comorbidities; and individuals in correction services. Establishing awareness of the messages regarding treatment from recent clinical practice guidelines (CPG) in the field is also of value. The first study objective will be to establish a greater understanding of the methods, populations, and findings of controlled studies for psychosocial and pharmacologic treatments for MUD and PMU. Investigation of this information can help establish the potential for advanced syntheses of the evidence (such as network meta-analysis) to compare therapies for this condition and to identify gaps related to key populations where more primary research is needed. Summarizing the recommendations regarding treatment of MUD/PMU from recent CPGs and systematic reviews will be an important secondary objective.
A scoping review will be performed. Using the OVID platform, MEDLINE, Embase, PsycINFO, and relevant Cochrane databases from EBM Reviews will be searched (from databases' inception onwards). Eligibility criteria will include individuals described as having MUD or PMU, with designs of interest including randomized trials, non-randomized trials, and controlled cohort studies with three or more months of follow-up; systematic reviews and CPGs will also be sought. Two reviewers (with support from automation tools) will independently screen all citations, full-text articles, and chart data. Different approaches to handling and summarizing the data will be implemented for each type of study design. Tables and graphics will be used to map evidence sources and identify evidence gaps.
This research will enhance awareness of evidence addressing the effects of psychosocial and pharmacologic interventions for MUD/PMU overall and in sub-populations, both in terms of recent CPGs/reviews and primary studies; inspection of the latter will also help establish the feasibility of future syntheses to compare treatments, such as network meta-analysis. SYSTEMATIC REVIEW PROTOCOL REGISTRATION: Open Science Framework ( https://osf.io/9wy8p ).
甲基苯丙胺的使用和危害正在迅速增加。治疗甲基苯丙胺使用障碍（MUD）和有问题的甲基苯丙胺使用（PMU）的患者具有挑战性，因为没有明确的最佳方法；心理社会和药理学干预措施都有描述。此外，鉴于使用甲基苯丙胺的个体的多样性，需要评估针对包括青少年在内的亚组的治疗方法的证据；男同性恋、双性恋和其他与男性发生性关系的男性；有精神健康合并症的个体；以及在惩教服务中的个体。了解该领域最近的临床实践指南（CPG）中关于治疗的信息也很有价值。第一项研究目标将是更好地了解针对 MUD 和 PMU 的心理社会和药理学治疗的对照研究的方法、人群和结果。调查这些信息可以帮助确定对该疾病的证据进行高级综合（如网络荟萃分析）的潜力，以比较治疗方法，并确定与关键人群相关的差距，这些人群需要更多的初级研究。总结最近 CPG 和系统评价中关于 MUD/PMU 治疗的建议将是一个重要的次要目标。
将进行范围审查。使用 OVID 平台，将在 MEDLINE、Embase、PsycINFO 和 EBM Reviews 的相关 Cochrane 数据库中进行搜索（从数据库成立之日起）。合格标准将包括被描述为患有 MUD 或 PMU 的个体，感兴趣的设计包括随机试验、非随机试验和有三个月或更长时间随访的对照队列研究；也将寻找系统评价和 CPG。两名评审员（在自动化工具的支持下）将独立筛选所有引用、全文文章和图表数据。将为每种研究设计实施不同的方法来处理和总结数据。表格和图形将用于映射证据来源并确定证据差距。
这项研究将提高对整体和亚人群中针对 MUD/PMU 的心理社会和药理学干预效果的证据的认识，包括最近的 CPG/综述和初级研究；对后者的检查也将有助于确定未来比较治疗方法（如网络荟萃分析）综合的可行性。
Open Science Framework（https://osf.io/9wy8p）。
