预防左乙拉西坦引起的全血细胞减少症伴外伤性硬脑膜外血肿：病例报告。
Prophylactic levetiracetam-induced pancytopenia with traumatic extra-dural hematoma: Case report.
机构信息
Department of Neurosurgery, Sir Charles Gairdner Hospital (SCGH), Perth, WA, Australia.
Department of Neurosurgery, Sir Charles Gairdner Hospital (SCGH), Perth, WA, Australia.
出版信息
J Clin Neurosci. 2020 Oct;80:264-266. doi: 10.1016/j.jocn.2020.08.004. Epub 2020 Sep 7.
BACKGROUND
Pancytopenia has only rarely been reported with Levetiracetam use. It is a potentially life threatening adverse effect that requires cessation of therapy.
CASE DESCRIPTION
We describe a case of an otherwise well thirty-two-year-old man who underwent an emergent craniotomy for evacuation of a traumatic extra-dural haematoma. Post-operatively, he developed pancytopenia which corrected with cessation of levetiracetam.
CONCLUSION
This report aims to increase awareness of this rare side effect and reiterates the judicious use of prophylactic levetiracetam in brain trauma.
背景
左乙拉西坦极少引起全血细胞减少。这是一种潜在的危及生命的不良反应，需要停止治疗。
病例描述
我们描述了一个 32 岁的健康男性患者的病例，该患者因创伤性硬膜外血肿而行紧急开颅手术。术后，他出现全血细胞减少，停止使用左乙拉西坦后得到纠正。
结论
本报告旨在提高对这种罕见副作用的认识，并再次强调在脑外伤中预防性使用左乙拉西坦时要谨慎。
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