SNP c.907+75C>T 与前列腺癌风险的关联受晒黑潜能的影响。
The Association Between the Genetic SNP c.907+75C>T and Prostate Cancer Risk Is Modified by Tanning Potential.
机构信息
Cancer Center, Howard University, Washington, DC, U.S.A.
Community and Family Medicine, College of Medicine, Howard University, Washington, DC, U.S.A.
出版信息
Cancer Genomics Proteomics. 2020 Nov-Dec;17(6):739-745. doi: 10.21873/cgp.20228.
BACKGROUND
Prostate cancer (PCa) is a multifactorial disease involving complex interactions between genetic and physiological/environmental factors. Vitamin D receptor (VDR) plays a role in numerous cellular pathways and it has been suggested that VDR genetic variants influence individual susceptibility to PCa.
MATERIALS AND METHODS
Logistic regression analysis was used to assess the association of six VDR single nucleotide polymorphisms (SNPs) and factors such as tanning potential and UV sunlight exposure with PCa risk.
RESULTS
Marginal significant interactions were found, with a 2-fold increase risk of PCa between SNP 1 (c.278-69G>A) and sunlight UV exposure [odds ratio (OR)=2.02, 95% confidence intervaI (CI)=1.036-4.36; p=0.05]; and a 4-fold increase risk of PCa between SNP 4 (c.907+75C>T) and tanning potential (OR=4.40, 95% CI=0.89-29.12; p=0.0591). In contrast, SNP 5 (rs731236, TaqI) and tanning potential interaction had a protective effect by reducing the risk of PCa by 55% (β=-0.804; OR=0.448, 95% CI=0.197-9.42; p=0.0427). SNPs 2 (rs61614328) and 6 (rs533037428) did not show any association with PCa even in the presence of UV sunlight exposure.
CONCLUSION
The protective effect of SNP 4 from PCa is lost and modified by tanning potential in African Americans. This finding needs to be verified by larger studies in different ethnic populations.
背景
前列腺癌（PCa）是一种多因素疾病，涉及遗传和生理/环境因素之间的复杂相互作用。维生素 D 受体（VDR）在许多细胞途径中发挥作用，并且已经表明 VDR 遗传变异影响个体对 PCa 的易感性。
材料和方法
使用逻辑回归分析来评估六个 VDR 单核苷酸多态性（SNP）与晒黑潜力和紫外线阳光暴露等因素与 PCa 风险的关联。
结果
发现了边缘显著的相互作用，SNP 1（c.278-69G>A）与阳光紫外线暴露之间 PCa 的风险增加了 2 倍（比值比（OR）=2.02，95%置信区间（CI）=1.036-4.36；p=0.05）；SNP 4（c.907+75C>T）与晒黑潜力之间 PCa 的风险增加了 4 倍（OR=4.40，95% CI=0.89-29.12；p=0.0591）。相比之下，SNP 5（rs731236，TaqI）与晒黑潜力的相互作用具有保护作用，使 PCa 的风险降低了 55%（β=-0.804；OR=0.448，95% CI=0.197-9.42；p=0.0427）。即使存在紫外线阳光暴露，SNP 2（rs61614328）和 6（rs533037428）也与 PCa 没有任何关联。
结论
SNP 4 对 PCa 的保护作用在非裔美国人中被晒黑潜力所削弱和改变。这一发现需要在不同种族人群中进行更大规模的研究来验证。
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