登革热和感染后疲劳：一项前瞻性队列研究的结果——科伦坡登革热研究。
Dengue and post-infection fatigue: findings from a prospective cohort-the Colombo Dengue Study.
机构信息
Department of Parasitology, Faculty of Medicine, University of Colombo, 00800, Colombo 08, Sri Lanka.
Department of Clinical Medicine, Faculty of Medicine, University of Colombo, 00800, Colombo 08, Sri Lanka.
出版信息
Trans R Soc Trop Med Hyg. 2021 Jun 2;115(6):669-676. doi: 10.1093/trstmh/traa110.
BACKGROUND
Previous studies on post-infection fatigue in dengue are few but suggest that up to 25% of dengue patients may suffer from fatigue. This study aimed to evaluate the prevalence and associations of post-infection fatigue in dengue patients compared with non-dengue fever patients.
METHODS
Post-infection fatigue and its demographic and clinical associations were assessed in adult dengue and non-dengue fever patients 2 months after the acute infection in a prospective cohort study in Sri Lanka. Fatigue at 2 months (primary endpoint) was assessed with the fatigue questionnaire as a dichotomous outcome based on a pre-recommended cut-off (score ≥4) and as the total score from the questionnaire (higher score indicates more fatigue).
RESULTS
Of 260 patients, 158 had dengue and, of these, 51 (32%) had fatigue at 2 months. Risk was higher in dengue patients (vs non-dengue; relative risk [RR] 4.93 [95% confidence interval {CI} 2.3 to 10.4]) and more so in female dengue patients (vs male dengue patients; RR 2.45 [95% CI 1.24 to 4.86]). Severe dengue patients had a higher mean fatigue score (p=0.024).
CONCLUSIONS
Post-infection fatigue is an underappreciated burden of this widely prevalent infection. Our findings are useful to triage patients at risk of fatigue for follow-up.
背景
既往关于登革热后感染性疲劳的研究较少，但提示多达 25%的登革热患者可能患有疲劳。本研究旨在评估与非登革热发热患者相比，登革热患者感染后疲劳的患病率和相关性。
方法
在斯里兰卡的一项前瞻性队列研究中，在急性感染后 2 个月，评估成年登革热和非登革热发热患者的感染后疲劳及其与人口统计学和临床特征的相关性。使用疲劳问卷评估 2 个月时的疲劳（主要终点），根据预先推荐的截止值（评分≥4）将疲劳分为二分类结局，也将问卷的总分作为衡量疲劳的指标（得分越高表示疲劳越严重）。
结果
在 260 例患者中，有 158 例患有登革热，其中 51 例（32%）在 2 个月时出现疲劳。与非登革热发热患者相比，登革热患者发生疲劳的风险更高（相对风险 [RR] 4.93 [95%置信区间 {CI} 2.3 至 10.4]），女性登革热患者（RR 2.45 [95% CI 1.24 至 4.86]）的风险更高。重症登革热患者的平均疲劳评分更高（p=0.024）。
结论
感染后疲劳是这种广泛流行感染的一个被低估的负担。我们的研究结果有助于对有疲劳风险的患者进行分诊以进行随访。
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