Foret Julie, Paren Anne-Julie, Zayet Souheil, Chirouze Catherine, Gendrin Vincent, Bouiller Kevin, Klopfenstein Timothée
Department of Infectious and Tropical Diseases, CHU Besançon, Besançon, France.
Department of Infectious and Tropical Diseases, Nord Franche-Comté Hospital, Trevenans, France.
Open Forum Infect Dis. 2025 Jan 24;12(2):ofaf042. doi: 10.1093/ofid/ofaf042. eCollection 2025 Feb.
Earlier studies revealed that 10%-50% of patients reported remaining complaints after treatment for Lyme neuroborreliosis (LNB). The aim of our study was to assess symptoms and quality of life in patients with diagnosed and treated LNB and to compare them with findings in the general population.
Adults with LNB receiving adequate antibiotics were included between 2015 and 2021 in 2 tertiary hospitals. Two controls without Lyme borreliosis history were included for each case patient, matched by age and geographic area. All participants were interviewed to answer a standardized questionnaire. Fatigue was assessed by the Fatigue Severity Scale (FSS) and quality of life by the 12-Item Short Form Survey, including physical component summary (PCS) and mental component summary (MCS) scores.
Fifty-three patients and 104 controls were included. The mean age (SD) was 62 (13) years in both groups; 66% were male in the LNB group and 44% in the control group ( = .01). Fatigue (68% vs 48%, respectively; = .02), memory disorders (60% vs 38%; < .01), and attention disorders (32% vs 17%; = .05) were significantly more frequent in the LNB group than in controls. In multivariable analysis, no association was found between LNB and FSS scores (odds ratio, 1.6 [95% confidence interval, .9-3.0]; = .15) or between LNB and MCS scores (0.8 [.4-1.5]; = .45); however, patients with LNB had lower PCS scores (0.5 [.3-.9]; = .03).
Several symptoms were similar in patients with LNB and controls. Quality of life was slightly impaired in patients with LNB and PCS scores were lower, but there were no differences in MCS or FSS scores. Reassurance and specific rehabilitation measures could be provided to these patients.
早期研究表明，10%-50%的患者在接受莱姆病神经螺旋体病（LNB）治疗后仍有不适主诉。我们研究的目的是评估已确诊并接受治疗的LNB患者的症状和生活质量，并将其与普通人群的研究结果进行比较。
2015年至2021年期间，两家三级医院纳入了接受足量抗生素治疗的成年LNB患者。每例患者纳入两名无莱姆病病史的对照者，按年龄和地理区域进行匹配。所有参与者均接受访谈以回答一份标准化问卷。通过疲劳严重程度量表（FSS）评估疲劳情况，通过12项简明健康调查评估生活质量，包括躯体健康评分（PCS）和精神健康评分（MCS）。
纳入了53例患者和104名对照者。两组的平均年龄（标准差）均为62（13）岁；LNB组66%为男性，对照组44%为男性（P = 0.01）。LNB组的疲劳（分别为68%和48%；P = 0.02）、记忆障碍（60%和38%；P < 0.01）和注意力障碍（32%和17%；P = 0.05）明显比对照组更常见。在多变量分析中，未发现LNB与FSS评分之间存在关联（比值比，1.6[95%置信区间，0.9 - 3.0]；P = 0.15），也未发现LNB与MCS评分之间存在关联（0.8[0.4 - 1.5]；P = 0.45）；然而，LNB患者的PCS评分较低（0.5[0.3 - 0.9]；P = 0.03）。
LNB患者和对照者有几种症状相似。LNB患者的生活质量略有受损，PCS评分较低，但MCS或FSS评分无差异。可为这些患者提供安慰和特定的康复措施。
