Han Hongying, Xia Xiaowei, Zheng Huirong, Zhao Chongbang, Xu Yanming, Tao Jiong, Wang Xianglan
Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Affiliated School of Medicine of South China University of Technology, Guangzhou, China.
Psychiatry Investig. 2020 Nov;17(11):1073-1078. doi: 10.30773/pi.2020.0023. Epub 2020 Oct 27.
To investigate the association between gene polymorphism of vesicular monoamine transporter type 2(VMAT2) and schizophrenia in Han Chinese population.
430 patients with schizophrenia and 470 age-sex matched controls were recruited from four mental health centers. All patients were diagnosed by two psychiatrists based on the Structured Clinical Interview for DSM Disorders (SCID). The ligase detection reactions (LDR) method was used to assess the polymorphism of the two SNPs (rs363371 and rs363324) of VMAT2.
No associations of two SNPs with schizophrenia was found. When we stratified males and females for the analysis, we found that that in the recessive model of rs363371, there was an obvious significant association between rs363371 and schizophrenia in males (OR=0.564, 95% CI=0.357-0.892, p=0.014) but not females. For the association between rs363324 and schizophrenia, no association was found in either males or females. No association was found when stratifying early-onset schizophrenia and late-onset schizophrenia.
Our findings indicate that both rs363371 and rs363324 were not associated with schizophrenia, while it seemed that the AA genotype of rs363371 plays a protective effect in male Chinese in developing schizophrenia.
探讨2型囊泡单胺转运体（VMAT2）基因多态性与汉族人群精神分裂症之间的关联。
从四个精神卫生中心招募了430例精神分裂症患者和470例年龄及性别匹配的对照。所有患者均由两名精神科医生根据《精神疾病诊断与统计手册》结构化临床访谈（SCID）进行诊断。采用连接酶检测反应（LDR）方法评估VMAT2两个单核苷酸多态性（SNP，rs363371和rs363324）的多态性。
未发现这两个SNP与精神分裂症有关联。当我们按性别分层进行分析时，发现在rs363371的隐性模型中，rs363371与男性精神分裂症之间存在明显的显著关联（OR = 0.564，95%可信区间= 0.357 - 0.892，p = 0.014），而女性中未发现。对于rs363324与精神分裂症之间的关联，男性和女性均未发现关联。按早发型精神分裂症和晚发型精神分裂症分层时未发现关联。
我们的研究结果表明，rs363371和rs363324均与精神分裂症无关，而rs363371的AA基因型似乎对中国男性患精神分裂症具有保护作用。
