Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.
Department of Human Biochemistry, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
Comb Chem High Throughput Screen. 2021;24(9):1492-1502. doi: 10.2174/1386207323666201023120212.
Perimenopause is a physiological occurrence in women, and is characterized by endocrine and biochemical changes. During perimenopause phase, many derangements or abnormal health conditions start developing as a result of hormonal changes. These derangements in health conditions and biochemical changes lead to higher incidence of metabolic syndrome (MetS) occurrence with or without bone involvement. There is a scarcity of information on MetS in Enugu, Southern Nigeria and there is no available data on the correlation of selected bone-related biochemicals with endocrine parameters and MetS in perimenopausal women from the region.
We consecutively sampled 200 apparently healthy women, and categorized them into 120 perimenopausal women (age (!) = 50years) and a second group of 80 women in premenopause (age (!) = 35years). Measurement of anthropometric indices like blood pressure, height, weight and waist circumference were taken. Fasting blood samples were collected for the estimation of endocrine parameters (estradiol (E₂), follicle stimulating hormone (FSH), and luteinizing hormone (LH)) using enzyme linked immunosorbent assay (ELISA) technique. The lipid profile, fasting plasma glucose (FPG), uric acid, inorganic phosphate, calcium and alkaline phosphatase levels were determined using standard biochemical methods. The evaluation of MetS was carried out in the women using the three different criteria: World Health Organization (WHO), National Cholesterol Education Program- Adult Treatment Panel 111 (NCEP-ATP 111) and International Diabetes Federation (IDF). For statistical analysis, Student's t-test, Pearson correlation and Chi-square were used to compare categorical and continuous variables.
Calcium was predominantly high in the three criteria (p<0.05). LH and FSH showed a positive correlation with FPG while E₂ was negatively associated with FPG. Similarly, LH showed a positive association with inorganic phosphate while E₂ was negatively associated with alkaline phosphatase (p<0.05).
Perimenopausal women are at higher risk of developing osteoporosis than premenopausal women. This emphasizes the need for timely diagnosis of osteoporosis in perimenopausal women.
围绝经期是女性的一种生理现象，其特征为内分泌和生化变化。在围绝经期，由于激素变化，许多健康紊乱或异常状况开始出现。这些健康状况的紊乱和生化变化导致代谢综合征（MetS）的发生率更高，无论是否伴有骨骼受累。在尼日利亚南部的埃努古，有关 MetS 的信息很少，而且该地区也没有关于围绝经期女性中某些与骨骼相关的生化指标与内分泌参数和 MetS 之间相关性的可用数据。
我们连续采集了 200 名看似健康的女性，将其分为 120 名围绝经期女性（年龄（！）= 50 岁）和 80 名绝经前女性（年龄（！）= 35 岁）。测量了血压、身高、体重和腰围等人体测量学指标。采集空腹血样，采用酶联免疫吸附试验（ELISA）技术测定内分泌参数（雌二醇（E₂）、卵泡刺激素（FSH）和黄体生成素（LH））。采用标准生化方法测定血脂谱、空腹血糖（FPG）、尿酸、无机磷、钙和碱性磷酸酶水平。采用世界卫生组织（WHO）、美国国家胆固醇教育计划-成人治疗专家组 111（NCEP-ATP 111）和国际糖尿病联盟（IDF）三种不同标准评估 MetS。采用学生 t 检验、Pearson 相关和卡方检验比较分类和连续变量。
在三种标准中，钙均显著升高（p<0.05）。LH 和 FSH 与 FPG 呈正相关，而 E₂与 FPG 呈负相关。同样，LH 与无机磷呈正相关，而 E₂与碱性磷酸酶呈负相关（p<0.05）。
围绝经期女性发生骨质疏松的风险高于绝经前女性。这强调了及时诊断围绝经期女性骨质疏松症的必要性。
