Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University.
Division of Regeneration and Medicine, Hiroshima University Hospital.
J Atheroscler Thromb. 2021 Sep 1;28(9):963-973. doi: 10.5551/jat.59261. Epub 2020 Oct 23.
Volume elastic modulus (V), an index of arterial elasticity, and arterial diameter of the brachial artery can be automatically measured by a newly developed oscillometric device. We investigated the associations of V with flow-mediated vasodilation (FMD), an index of endothelium-dependent vasodilation, nitroglycerine-induced vasodilation (NID), an index of endothelium-independent vasodilation, and intima-media thickness (IMT) of the brachial artery and association of oscillometrically measured brachial artery diameter with ultrasonographically measured brachial artery diameter in patients with cardiovascular risk factors.
Oscillometric measurements of V and brachial artery diameter and ultrasound measurements of brachial artery diameter, FMD, NID, and IMT of the brachial artery were performed in 50 patients with cardiovascular risk factors.
The mean values were 2.1±0.4 mmHg/% for V, 0.31±0.05 mm for brachial IMT, 4.48±0.70 mm for oscillometric brachial artery diameter, and 4.30±0.55 mm for ultrasound brachial artery diameter. V significantly correlated with brachial IMT (r=0.51, P＜0.001), whereas there was no significant correlation of V with FMD (r=-0.08, P=0.58) or NID (r=0.07, P=0.61). Multivariate analysis revealed that V was significantly associated with brachial IMT (β=0.33, P=0.04). Oscillometric brachial artery diameter significantly correlated with ultrasound brachial artery diameter (r=0.79, P＜0.001). The Bland-Altman plot showed good agreement between oscillometric brachial artery diameter and ultrasound brachial artery diameter (mean difference, -0.17 mm; limits of agreement, -1.03 mm to 0.69 mm).
In patients with cardiovascular risk factors, V may represent atherosclerotic structural alterations of the vascular wall but not vascular function. The accuracy of oscillometric measurement of brachial artery diameter is acceptable.
体积弹性模量（V）是动脉弹性的一个指标，可以通过新开发的振荡测量仪自动测量。我们研究了 V 与血流介导的血管扩张（FMD）、内皮依赖性血管扩张的指标、硝酸甘油诱导的血管扩张（NID）、内皮非依赖性血管扩张的指标以及肱动脉内-中膜厚度（IMT）的相关性，以及心血管危险因素患者中振荡测量的肱动脉直径与超声测量的肱动脉直径的相关性。
对 50 例心血管危险因素患者进行振荡测量 V 和肱动脉直径以及超声测量肱动脉直径、FMD、NID 和肱动脉 IMT。
V 的平均值为 2.1±0.4mmHg/%，肱动脉 IMT 为 0.31±0.05mm，振荡测量的肱动脉直径为 4.48±0.70mm，超声测量的肱动脉直径为 4.30±0.55mm。V 与肱动脉 IMT 显著相关（r=0.51，P＜0.001），而 V 与 FMD（r=-0.08，P=0.58）或 NID（r=0.07，P=0.61）无显著相关性。多元分析显示，V 与肱动脉 IMT 显著相关（β=0.33，P=0.04）。振荡测量的肱动脉直径与超声测量的肱动脉直径显著相关（r=0.79，P＜0.001）。Bland-Altman 图显示，振荡测量的肱动脉直径与超声测量的肱动脉直径之间具有良好的一致性（平均差值，-0.17mm；一致性界限，-1.03mm 至 0.69mm）。
在心血管危险因素患者中，V 可能代表血管壁的动脉粥样硬化结构改变，而不是血管功能。振荡测量肱动脉直径的准确性是可以接受的。
