Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences.
Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University.
J Hypertens. 2018 Jul;36(7):1460-1467. doi: 10.1097/HJH.0000000000001750.
: Vascular response to exogenously administered nitroglycerine, an index of endothelium-independent vasodilation, has been used as a control test for the assessment of endothelium-dependent vasodilation (endothelial function) in humans. However, evidence has been accumulating that not only endothelium-dependent vasodilation but also endothelium-independent vasodilation per se is impaired in individuals with cardiovascular risk factors and cardiovascular disease. Impaired endothelium-independent vasodilation is associated with structural vascular alterations and alterations in vascular smooth muscle cells. Several methods, including assessment of vascular responses to vasoactive agents using angiography in a coronary artery and vascular responses to vasoactive agents using venous occlusion plethysmography and ultrasonography in a peripheral artery, are used to assess endothelium-independent vasodilation in humans. Measurement of endothelium-independent vasodilation is also useful for assessment of atherosclerosis and may be a predictor of future cardiovascular events. In this review, we focus on assessment of endothelium-independent vasodilation from methodology aspects to clinical perspectives.
血管对给予的硝酸甘油的反应，即内皮非依赖性血管舒张的指标，已被用作评估人类内皮依赖性血管舒张（内皮功能）的对照试验。然而，越来越多的证据表明，不仅内皮依赖性血管舒张，而且内皮非依赖性血管舒张本身在具有心血管危险因素和心血管疾病的个体中受损。内皮非依赖性血管舒张受损与结构血管改变和血管平滑肌细胞改变有关。有几种方法可用于评估人类的内皮非依赖性血管舒张，包括使用冠状动脉血管造影评估血管对血管活性药物的反应和使用外周动脉血管闭塞容积描记法和超声评估血管对血管活性药物的反应。内皮非依赖性血管舒张的测量也可用于评估动脉粥样硬化，并且可能是未来心血管事件的预测因子。在这篇综述中，我们从方法学角度到临床观点重点关注内皮非依赖性血管舒张的评估。
